Type 1- 1 Flashcards
What type of hypersz is associated with intestinal worms?
TYPE 1
What type hypersz exaggerates the T helper cells response?
Type 1
Type 1 = excessive amount of Ig__ —> atopy
E
Type 1 = genes and environmental factors = ________
Allergies
After a vx, what 2 types increase?
1 and 3
Type 1= IL-__ overproduction
4
IL-4 overproduction = ________ Th2 activation and B cell stimulation
Increased
FcER = ________ affinity and irreversible binding
Increases
FCE__ = present in mast cells, basophils, neutrophils, eosinophils, macrophages, and DCs
I
FCE ____ = present in B cells, NK cells, macrophages, DCs, eosinophils, and platelets
II
Type 1:
1) Mast cell with IgE and antigen
2) Degranulation
3) Acute __________ and systemic effects
Inflammation
Bio active molecules are released by mast cells and basophil when antigen cross-links 2 Ig__ molecules on mast cell surface
E
IL- 4 produced by Th2 —> released —> promotes development of more Th2 = major sources of this cytokine promotes Ig __ responses
E
What cells may serve as an initial source of IL-4?
NK cells
What is inhibited by IFN-y and IL-12?
IL-4
What cells express trimeric FcERI?
DCs
Allergy Loop:
DCs express trimeric FcERI —> binds antigen Ig-E complexes = simulated Th__ response = secrete cytokines = promote IgE response
2
What complement receptors is located in B, T, and DC cells?
2
What cells have the following characteristics:
-CR2
-Located in intestine, skin, airways, around nerves,
-Close to blood vessels,
-Release pro-inflammatory mediators
Mast cells
