Two Compartment Model Of Dialysis Flashcards
1
Q
Why is single compartment not completely correct?
A
Sequential measurements of urea in the single compartment model showed transient rise behaviour
2
Q
Which are the two compartments of this model?
A
Intercellular
Extracelluar
3
Q
How do you calculate level?
A
Urea-extracell = INT (urea generation rate + compartmental transfer rate- urea elimination rate) •mmol Initial value: 45 x 42/3 (Assumed start conc. Of urea) x 1/3 TBW
4
Q
Level
A
Urea - INTRAcell= INT (-compartmental transfer rate)
•mmol
• 45 x 42 x 2/3
5
Q
Urea generation rate
A
Urea generation rate : 6,3 mmol/hour
6
Q
Urea elimination rate
A
Same as for single compartment dialysis
7
Q
Dialyzer clearance
A
200x 60/ 1000 l/hour
8
Q
Compartmental transfer rate
A
Concentration diff x compartmental mass transfer co-efficient
•unit: mmol/ hour
9
Q
Graphical representation
A
We now see desired effect:
A transient equilibrium at the end of each dialysis session - urea rebounds briefly - describes this phenomenon
