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pharmacology > tutorials > Flashcards

tutorials Flashcards

1
Q

how warfarins effect might be increased

A

by other drugs like clarithromycin- less metabolism by P450 enzymes as competing for same site: also with age ie less GFR+ metabolism, and malnutrition (less plasma proteins)

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2
Q

INR

A

how long it takes blood to clot- its ratio, so if lower, it clots FASTER ie warfarin increases INR

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3
Q

why older ppl need lower dose than younger, and CNS drugs specifically

A

less liver and kidney ie less metabolism and excretion- also more senstiive to CNS drugs eg benzodiazepines

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4
Q

how drugs overdosed/underdosed

A

food intake (better on empty stoamch), fluid (helps with absorption), age (newborns and elderly less metabolism/excretion), NON-COMPLIANCE, other diseases like GI disorders (less absoprtion), nutrition

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5
Q

ACH in respiratory system mimicks what nerve

A

vagus

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6
Q

graph of effect of metacholine (muscarinic agonist) on airway resistance ie shape

A

sigmoid curve

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7
Q

what is GTN

A

organic nitrate ie produces NO to vasodilate

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pharmacology (34 decks)

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