anti-virals

Question 1

treatment of viral hepatitis- hep B and C, acute or chronic, and most effective

Answer 1

TENOFOVIR is a nucleoside analogue to treat ONLY CHRONIC hep B, RIBAVIRIN is a nucleoside analogue to treat CHRONIC hep C, BOCEPREVIR also treat hep C- most effective, and is a protease inhibitor

Question 2

hep B vs hep c treatment and type of virus

Answer 2

can’t be cured vs aim is to cure- DNA vs RNA virus

Question 3

how HIV gets into cell and replicates+ type of virus- entry, replication/integration, assembly and release: mention GP41

Answer 3

RETROVIRUS- viral membrane protein GP120 attach to CD4 receptor+ CCR5 and gets in via endocytosis (GP41 penetrates membrane)- reverse transcriptase then causes RNA= DNA in cytoplasm, and DNA goes into nucleus and incorporates into host DNA via integrase= host cell machinery then produces viral RNA as well as proteins (HIV PROTEASE converts GAP PRECURSOR into these proteins), assembly then occurs and viral particle released

Question 4

HIV drugs inhibiting attachment+ entry

Answer 4

ENFUVIRTIDE (binds to GP41 protein), MARAVIROC (blocks CCR5)

Question 5

HIV drugs inhibiting replication

Answer 5

nucleoside RT inhibitors like ZIDOVUDINE and TENOFOVIR (work via phosphorylation), as well non-nucleoside RT inhibitors (EFAVIRENZ)

Question 6

HIV drugs inhibiting via integration

Answer 6

RALTEGRAVIR inhibits integrase

Question 7

HIV drugs inhibiting assembly and release+ booster

Answer 7

protease inhibitors SAQUINAVIR, given with a booster called RITONAVIR

Question 8

what kind of virus HSV is, treatment of HSV

Answer 8

DNA virus- nucleoside analogue called ACYCLOVIR

Question 9

influenza- type of virus, key enzyme and treatment

Answer 9

RNA virus,neuraminidase needed for it to work- neuraminidase inhibitor called OSELTAMIVIR used