Tutorial 1 Flashcards

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1
Q

What is accuracy?

A

The degree where the result of a measurement, calculation, or specification conforms to the correct value/standard.

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2
Q

What is precision?

A

A measure of repeatability quotes as absolute standard deviation (SD) or relative standard deviation (RSD).

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3
Q

How can we show high accuracy and high precision?

A

All measurements in middle together.

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4
Q

How can we show low accuracy and high precision?

A

All measurements away from the middle but together.

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5
Q

How can we show high accuracy and low precision?

A

All measurements near the middle but away from each other.

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6
Q

How can we show low accuracy and low precision?

A

All measurements away from the middle and away from each other.

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7
Q

What is the difference between a heterogeneous mixture and a homogenous mixture?

A

Homogenous mixture :
Intimately mixed on a small scale.

Heterogenous mixture :
Components not intimately mixed.

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8
Q

What are some examples of a homogeneous mixture?

A
Gases in atmosphere.
Ions in solution.
Very finely ground solid mixture.
One part of mixture has all components in same proportions.
Representative of whole.
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9
Q

What are some examples of a heterogeneous mixture?

A

Insoluble solid in liquid.
Stones and sand.
Rain falling.
Different portions with components in different proportions.
No small part is representative of whole.

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10
Q

Why is sample integrity important?

A

To make sure the correct samples is subjected to the right analysis.

The results go to the right place.

Nothing happens to sample that will endanger analysis.

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11
Q

What does integrity of the sample involve?

A

Ensuring correct sample.
Not changed.
Correct storage.

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12
Q

How can we make sure it is the correct sample?

A

Correct labelling.
Correct information recording.
Powerful checking pathway.

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13
Q

How can we make sure nothing has changed in samples?

A

Correct packaging.

Sealed tightly.

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14
Q

How can we make sure we storage samples correctly?

A

Keep cool in dark.
Free from air.
Contain acid.

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15
Q

Why might sample degradation during storage be a problem when analysing sample?

A

Result in increase/decrease of concentration will tested.

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16
Q

What happens to diazepam over time?

A

It degrades.

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17
Q

Where do metal ions form insoluble hydroxides?

A

In neutral/basic solutions.

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18
Q

When do solvents increase concentration?

A

When they evaporate.

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19
Q

Why should substances be kept in a desiccator?

A

To not absorb moisture by matrix and hydrolysed/dilute.

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20
Q

What happens to biological samples when they are not frozen at -80 degrees?

A

They degrade.

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21
Q

What is light?

A

A source of energy.

22
Q

What can light promote when samples are not kept in amber bottles in the dark?

A

Reactions.

23
Q

Why is quality assurance/quality control important for chemical analysis?

A

It is a way of preventing mistakes/errors in analytical results.

Avoiding problems in solutions/to customers.

24
Q

What happens to every component of an analytical procedure?

A

It is tested regularly.

Records are kept.

25
Q

What are the factors that are tested regularly in analytical procedures?

A
Volumetric flasks.
Pipettes.
Balances.
Instrumentation.
Method.
Calculation.
Powerful pathway/audit trail.
26
Q

What is the definition of a systematic error?

A

Not determined by chance.
Introduced by an inaccuracy.
Inherent in system.

27
Q

What can we do to the error if it is consistent and persistent?

A
Adjust it.
Recovery check. 
Spike matrix with known amount.
Carry full sample prep and analysis many times.
Divide result by mean.
Get true amount.
28
Q

A copper penny contains 7.15% copper.
What is the mean and standard deviation of the group?
Data = 7.25, 7.45, 8.34, 7.41, 7.34.
Comment precision and accuracy.

A
Average = 7.56.
Standard deviation = 0.44
RSD = 5.82%.
Not really accurate.
Not really precise.
29
Q

What does integrity of the sample involve?

A

Ensuring correct sample identity.

Ensuring nothing changed.

30
Q

Which 3 factors ensure it is the correct sample?

A

Traceability.
Good record keeping.
Secure storage.

31
Q

Which are the 4 factors that help to ensure the integrity of an analytical procedure and its outcome?

A
  1. Chain care of sample and correct labelling.
  2. Secure storage.
  3. Cleanliness.
  4. Correct storage.
32
Q

How can we make sure about sample’s integrity with chain care of the sample and correct labelling?

A

Powerful pathway.

Sign in and out.

33
Q

How can we make sure about sample’s integrity with secure storage?

A

Avoiding tampering.

Locked doors, cupboard, fridges.

34
Q

How can we make sure about sample’s integrity with cleanliness?

A

Avoid contamination.
Day to day cleaning.
Deep regular cleans.

35
Q

How can we make sure about sample’s integrity with correct storage?

A
Prevent chemical reactions.
Sample did not change.
Cold storage.
Under inert atmosphere.
In dark.
36
Q

What happens at -80 degrees?

A

Everything stops for a long time.

Samples are not degraded.

37
Q

What happens when samples come in contact with water?

A

Reaction stops.

38
Q

Where does the sample’s storage depend?

A

On sample’s nature.

39
Q

How do chemists storage solutions normally?

A

Freeze.
Evaporate.
Store in freezer.

40
Q

What does assurance help?

A

Quality of work.

High standards.

41
Q

What does everything in the lab need to be?

A

Accredited.

42
Q

How can material and processes in lab be accredited?

A

Regularly testing.

43
Q

What happens to the out of day material?

A

Not used.

44
Q

What happens to the flasks when they dry in the oven?

A

Change sheep.

Change scale measurement.

45
Q

What must we do to all the used flasks?

A

Wash them.

46
Q

What does acetone do?

A

Soluble in water.
Evaporates.
Cleans flasks.

47
Q

What must we do in the laboratories?

A

Everything in best possible way.

48
Q

Why is RSD = 5.82% not accurate?

A

Far from 7.15.

49
Q

How do we know a process is more precise based on RSD?

A

< 2% = more precise.

> 2% = less precise –> reject.

50
Q

How do we call values really far from everything else?

A

Outliners.

51
Q

What must we know before we enter the laboratory?

A

Samples.
People.
Data.
Everything.