tumour lysis syndrome

Question 1

defin tumour lysis syndrome

Answer 1

a group of metabolic abnormalities that can occur as a complication during treatment of cancer

Question 2

what are the lab requirements of TLS?

Answer 2

o high potassium
o high phosphate
o low calcium
o high uric acid

Question 3

what needs to be present for a clinical diagnosis of TLS?

Answer 3

o Increased serum creatinine
o Cardiac arrhythmia or sudden death
o Seizure

Question 4

main risk factor for TLS?

Answer 4

chemotherapy for lymphoma or leukemia

Question 5

what is the pathophysiology?

Answer 5

when too many tumour cells are killed to quickly they release toxins into the body and there is metabolic disregulation

Question 6

main presenting symptoms of TLS?

Answer 6

• signs of Hyperkalaemia
• signs of Hyperphosphataemia
• signs of Hypocalcaemia
• signs of Hyperuricaemia
• signs of Lactic Acidosis

Question 7

main investigation for TLS?

Answer 7

•	Check the levels of all the metabolites that are deranged: 
o	Potassium 
o	Phosphate  
o	Calcium 
o	Uric acid  

• Monitor for symptoms:
o Increased serum creatinine
o Arrhythmia
o Seizure