squamous cell carcinoma

Question 1

define squamous cell carcinoma?

Answer 1

malignancy of epidermal keratinocytes of the skin

Question 2

what is Marjolin’s ulcer?

Answer 2

squamous cell carcinoma that arises in an area of chronically inflamed skin

Question 3

main risk factor of squamous cell carcinoma ?

Answer 3

UV RADIATION

Question 4

what are other risk factors of squamous cell carcinoma ?

Answer 4

o	Radiation  
o	Smoking 
o	Chronic skin disease (e.g. lupus) 
o	HPV  
o	Long-term immunosuppression 
o	Defects in DNA repair

Question 5

epidemiology of squamous cell carcinoma?

Answer 5

• SECOND most common cutaneous malignancy
• MIDDLE-AGED and ELDERLY people
• LIGHT-SKINNED individuals are at higher risk
• LOOK out for the immunosuppressed
• more common in men

Question 6

presenting signs and symptoms of squamous cell carcinoma?

Answer 6

• Skin lesion - may be ulcerated, hyperkeratotic, crusted or scaly, non-healing
• Ulcerated
• Recurrent bleeding
• Non-healing
• Lymphadenopathy

Question 7

best investigation for squamous cell carcinoma?

Answer 7

• Skin Biopsy to confirm malignancy