Tumor-Targeting antibodies and neutrophils Flashcards
What effects can monoclonal antibodies have?
They can have direct effects, can activate the complement or activate immune cells by binding the Fc receptor.
Why are neutrophils effective against tumors?
Neutrophils can effectively induce antibody-dependent cellular cytotoxicity (ADCC) to cancer cells.
Neutrophils can easily be mobilized from the bone marrow (with G-CSF), so you don’t have to isolate and readministrate them.
Neutrophils can secrete chemotactic stimuli attracting other immune cells.
How do neutrophils kill tumor cells?
They form tight synapses with tumor cells and pull the tumor cells apart (trogocytosis). Trogocytosis can lead to cell death (trogoptosis).
What are bispecific antibodies?
Bispecific antibodies are made of two different arms that target different things. They made a bispecific antibody with a anti-EGFD and a anti-FcaRI arm, so they will bind both tumor cells and neutrophils.
What effect does blocking SIRPa-CD47 have?
Blocking SIRPa-CD47 enhances tumor cell killing by neutrophils. You will remove negative checkpoint regulation.
What are the advantages of using IgA as a stimulus for neutrophils?
IgA is an extremely potent activating stimulus for neutrophils, induces phagocytosis, the release of NETs/inflammatory mediator,s and migration of neutrophils. The process is dependent on FcaRI. The downside is a short half-life.
