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Neoplasia > Tumor supressor genes - gene product 236 > Flashcards

Tumor supressor genes - gene product 236 Flashcards

1
Q

BRCA1

A

DNA repair protein

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2
Q

MEN1

A

menin

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3
Q

NF 1

A

Ras GTPase activating protein (inactivates ras)

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4
Q

p16

A

cyclin-dependent kinase inhibitor 2A

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5
Q

p53

A

transcription factor for p21, blocks G1->S phase

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6
Q

Rb

A

inhibits E2F
(binds E2F when phosphorylated)
blocks G1->S phase

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7
Q

VHL

A

Inhibits hypoxia inducible factor 1a

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Neoplasia (4 decks)

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