Tumor supressor genes Flashcards

1
Q

APC

A

colorectal cancer

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2
Q

BRCA1/BRCA2

A

Breast and ovarian cancer

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3
Q

DCC

A

colon cancer

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4
Q

DPC4/SMAD4

A

pancreatic cancer

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5
Q

MEN1

A

MEN1

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6
Q

NF1

gene product

A

neurofibromatosis 1

Ras GTPase activator (turns off ras

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7
Q

p16

A

melanoma

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8
Q

p53

A

most cancers

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9
Q

PTEN

A

Breast cancer, prostate cancer, endometrial cancer

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10
Q

Rb

A

retinoblastoma, osteosarcoma

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11
Q

TSC1

A

Tuberous sclerosis

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12
Q

TSC2

A

Tuberous sclerosis

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13
Q

VHL

A

RCC, VHL disease

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14
Q

WT1/WT2

A

Wilms tumor (nephroblastoma)

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