Tumor supressor genes Flashcards
1
Q
APC
A
colorectal cancer
2
Q
BRCA1/BRCA2
A
Breast and ovarian cancer
3
Q
DCC
A
colon cancer
4
Q
DPC4/SMAD4
A
pancreatic cancer
5
Q
MEN1
A
MEN1
6
Q
NF1
gene product
A
neurofibromatosis 1
Ras GTPase activator (turns off ras
7
Q
p16
A
melanoma
8
Q
p53
A
most cancers
9
Q
PTEN
A
Breast cancer, prostate cancer, endometrial cancer
10
Q
Rb
A
retinoblastoma, osteosarcoma
11
Q
TSC1
A
Tuberous sclerosis
12
Q
TSC2
A
Tuberous sclerosis
13
Q
VHL
A
RCC, VHL disease
14
Q
WT1/WT2
A
Wilms tumor (nephroblastoma)