tumor suppressors/oncogenes

Question 1

erb-B2

Answer 1

oncogene in breast, ovary, lung cancer

gene product = EGFR

amplification

Question 2

abl

Answer 2

onocogene in CML, ALL

gene product= bcr-abl fusion protein with Tyrosine kinase

Question 3

n-myc

Answer 3

n=neuroblastoma

oncogene in neuroblastoma

nuclear regulatory protein

amplification

Question 4

sis

Answer 4

oncogene that encodes PDGF (mitogen for fibroblasts, SMCs, and glial cells

tumor= astrocytoma

Question 5

n-myc

Answer 5

onocogene in neuroblastoma

Question 6

c-met

Answer 6

oncogene encodes a receptor for HGF(hepatocyte growth factor) in papillary renal cell carcinomas

Question 7

c-ret

Answer 7

protooncogene in MEN II,III and familial thyroid cancer

Question 8

ras

Answer 8

proto-ononcogene that codes for p21, GTP binding protein

colon, pancreas, lung cancer

Question 9

Rb

Answer 9

tumor suppressor seen in retinoblastoma

Question 10

BRCA1,2

Answer 10

tumor suppressor and repairs DNA DSB repair

breast, ovarian cancer

Question 11

p53

Answer 11

tumor suppressor

Li-Fraumeni syndrome

Question 12

APC

Answer 12

tumor suppressor

familial adenomatous polyposis colorectal cancer

Question 13

NF1,2

Answer 13

tumor suppressors

Neurofibromatosis