Tumor markers Flashcards
1
Q
cytokeratins
A
carcinomas, mesotheliomas
2
Q
CEA
A
adenocarcinomas of endodermal origin (**colon, lung, pancreas, stomach, breast)
3
Q
AFP
A
(alpha-fetoprotein) hepatocellular carcinomas, germ cell tumors/yolk sac carcinoma
4
Q
beta-hCG
A
choriocarcinoma(cancer of uterus), trophoblastic tumors
5
Q
CA-125
A
ovarian cancer
6
Q
placental alkaline phosphatase
A
seminoma (germ cell tumor or testes)
7
Q
neuroendocrine tumors
A
chromogranins and synaptophysin
**also contain neuroendocrine granules upon electron microscopy
8
Q
sarcomas
A
vimentin and desmin, muscle specific actin (muscle tissue)
9
Q
lymphomas
A
LCA (leukocyte common antigen), Cluster Designations (CD)
10
Q
malignant melanomas
A
immunohistochemical staining for HMB-45 and S-100 protein
11
Q
astrocytes/glial cell neoplasms
A
glial fibrillary acidic protein (GFAP)
