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MOD II > tumor suppressor genes and their familial syndromes > Flashcards

tumor suppressor genes and their familial syndromes Flashcards

1
Q

APC

A

familial colonic polyps and carcinomas

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2
Q

NF1

A

neurofibromatosis type 1 (peripheral nerve sheath tumors)

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3
Q

NF2

A

neurofibromatosis type 2 (acoustic scwannoma and meningioma)

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4
Q

PTCH

A

gorlin syndrome (basal cell carcinoma, medulloblastoma, several benign tumors)

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5
Q

VHL

A

von hippel lindau syndrome (cerebellar hemangioblastoma, retinal angioma, renal cell carcinoma)

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6
Q

CHD1

A

familial gastric cancer

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7
Q

BRCA1, BRCA2

A

familial breast and ovarian carcionma, carcinomas of male breast, chronic lymphocyte leukemia

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8
Q

MSH2, MLH1, MSH6

A

hereditary nonpolyposis colon carcinoma

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9
Q

WT1

A

familial wilms tumor

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MOD II (4 decks)

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