Tumor Suppressor genes

Question 1

APC

Answer 1

(-) regulator of Beta catenin/WNT p-way

Colorectal cancer (assoc. with FAP)
Chrom5

Question 2

BRCA1/ BRCA2

Answer 2

DNA repair protein

Breast, ovarian, pancreatic cancer
Chrom 17/13

Question 3

CDKN2A

Answer 3

p16, blocks G1 to S

melanoma, pancreatic cancer

Question 4

DCC

Answer 4

DCC- deleted in Colon Cancer

Colon cancer

Question 5

SMAD4 (DP4)

Answer 5

DPC-Deleted in Pancreatic Cancer

pancreatic cancer

Question 6

MEN1

Answer 6

Menin

MEN1

Question 7

NF1

Answer 7

Neurofibromin (Ras GTPase activating protein)

NF Type 1
chrom 17

Question 8

NF2

Answer 8

Merlin (schwannomin) protein

NF type 2

Question 9

PTEN

Answer 9

(- ) regulator of PI3k/AKT pathway

Breast, prostate, & endometrial cancer

Question 10

Rb

Answer 10

Inhibits E2F; blocks G1 to S phase

Retinoblastoma
Chrom 13

Question 11

TP53

Answer 11

p53, activates p21, blocks G1 to S phase

Most human cancers, Li Fraumeni Syndrome
SBLA cancer syndrome (Sarcoma,Breast, Leukemia, Adrenal
Chrom 17

Question 12

TSC1

Answer 12

Hamartin protein
Tuberous Sclerosis
chrom 9

Question 13

TSC2

Answer 13

Tuberin protein
Tuberous Sclerosis
Chrom 16

Question 14

VHL

Answer 14

Inhibits hypoxia-inducible factor 1a

Renal tumors-Von Hippel-Lindau disease
Chrom 3

Question 15

WT1

Answer 15

TF that regulates urogenital development
Wilms tumor (nephroblastoma)
Chrom 11