Tumor Suppressor Genes Flashcards by Jessica Martin | Brainscape

Q

APC

A

Colorectal cancer (associated with FAP)

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Q

BRCA1

A

DNA repair protein

Breast and ovarian cancer

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Q

BRCA2

A

DNA repair protein

Breast and ovarian cancer

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Q

CPD4/SMAD4

A

DPC - Deleted in Pancreatic Cancer

Pancreatic Cancer

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Q

DCC

A

DCC - Deleted in Colon Cancer

Colon Cancer

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Q

MEN1

A

MEN type 1

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Q

NF1

A

RAS GTPase activating protein (neurofibromin)

NeuroFibromatosis type 1

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Q

NF2

A

Merlin (schwannomin) protien

NeuroFibromatosis type 2

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Q

p16

A

Cyclin-dependent kinase inhibitor 2A

Melanoma

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Q

p53

A

Transcription factor for p21, blocks G1–>S phase

Most human cancers, Li-Fraumeni syndrome

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Q

PTEN

A

Breast cancer, prostate cancer, endometrial cancer

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Q

Rb

A

Inhibits E2F; blocks G1–>S phase

RetinoBlastoma, osteosarcoma

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Q

TSC1

A

Hamartin protein

Tuberous sclerosis

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Q

TSC2

A

Tuberin protein

Tuberous sclerosis

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Q

VHL

A

Inhibits hypoxia inducible factor 1a

von Hippel-Lindau disease

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Q

WT1

A

Wilms Tumor (nephroblastoma)

Q

WT2

A

Wilms Tumor (nephroblastoma)