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Pathology FA > Oncogenes > Flashcards

Oncogenes Flashcards

1
Q

BCR-ABL

A

Tyrosine Kinase

CML, ALL

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2
Q

bcl-2

A

Anti-apoptotic molecule (inhibits apoptosis)

Follicular and undifferentiated lymphomas

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3
Q

BRAF

A

Serine/threonine kinase

Melanoma, non-Hodgkin lymphoma

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4
Q

c-kit

A 
Cytokine receptor (for stem cell factor)
Gastrointestinal stromal tumor (GIST)
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5
Q

c-myc

A

Transcription factor

Burkitt lymphoma

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6
Q

HER2/new (c-erbB2)

A

Tyrosine kinase

Breast, ovarian, and gastric carcinomas

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7
Q

L-myc

A

Transcription factor

Lung tumor

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8
Q

N-myc

A

Transcription factor

Neuroblastoma

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9
Q

Ras

A

GTPase

Colon cancer, lung cancer, pancreatic cancer

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10
Q

RET

A

Tyrosine kinase

MEN 2A and 2B, medullary thyroid cancer

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Pathology FA (8 decks)

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