Tumor Suppressor Genes

Question 0

BRCA1

Answer 0

Tumors:
Breast and ovarian cancer
Gene product:
DNA repair protein

Question 1

Gene: APC

Answer 1

Tumor:

Colonorectal cancer

Question 2

Gene:BRCA2

Answer 2

Tumors:
Breast and ovarian cancer
Gene product:
DNA repair protein

Question 3

Gene: CPD4/SMAD4

Answer 3

Tumors:
Pancreatic cancer
Gene product:
DPC- deleted in pancreatic cancer

Question 4

Gene:DCC

Answer 4

Tumors:
Colon cancer
Gene product:
DCC- deleted in colon cancer

Question 5

Gene:MEN1

Answer 5

Tumors:

MEN type 1

Question 6

Gene:NF1

Answer 6

Tumor:
Neurofibromatosis type 1
Gene product:
RAS GTPase activating protein(neurofibromin)

Question 7

Gene: NF2

Answer 7

Tumors:
Neurofibromatosis type 2
Gene product:
Merlin protein (schwannomin)

Question 8

Gene: p16

Answer 8

Tumors:
Melanoma
Gene product:
Cyclin-dependent kinase inhibitor 2A

Question 9

Gene: p53

Answer 9

Tumors:
Most human cancers, Li-Fraumeni syndrome
Gene product:
Transcription factor for p21, blocksG1-> S-phase

Question 10

Gene: PTEN

Answer 10

Tumors:

Breast cancer, prostate cancer, endometrial cancer

Question 11

Gene:

Rb

Answer 11

Tumors:
Retinoblastomas, osteosarcoma
Gene product:
Inhibit E2F; blocks G1-> S-phase

Question 12

Gene:
TSC1
TSC2

Answer 12

Tumors:
Tuberous sclerosis 
Gene product:
(1) hamartin protein
(2) tuberin protein

Question 13

Gene:

VHL

Answer 13

Disease:
von Hipple-Lindau disease
Gene product:
Inhibits hypoxia inducible factor 1a

Question 14

Gene:
WT1
WT2

Answer 14

Tumors:

Wilms tumor