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Pathology > Tumor markers/genes/viruses/etc 0422 > Flashcards

Tumor markers/genes/viruses/etc 0422 Flashcards

1
Q

abl

A

oncogene: CML; tyrosine kinase

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2
Q

c-myc

A

oncogene: burkitt lymphoma; TF

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3
Q

bcl-2

A

oncogene: follicular and undifferentiated lymphomas; anti-apoptotic molecule

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4
Q

erb-B2

A

oncogene: breast, ovarian, gastric carcinomas; tyrosine kinase

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5
Q

ras

A

oncogene: colon carcinoma; GTPase

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6
Q

L-myc

A

oncogene: lung tumor; TF

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7
Q

N-myc

A

oncogene: neuroblastoma; TF

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8
Q

ret

A

oncogene: MEN IIA and IIB; tyrosine kinase

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9
Q

c-kit

A

oncogene: gastrointestinal stromal tumor (GIST); cytokine receptor

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10
Q

Rb

A

tumor suppressor: retinoblastoma, osteosarcoma

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11
Q

p53

A

tumor suppressor: most human cancers, Li-Fraumeni syndrome

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12
Q

BRCA1

A

tumor suppressor: breast and ovarian cancer

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13
Q

BRCA2

A

tumor suppressor: breast cancer

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14
Q

p16

A

tumor suppressor: melanoma

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15
Q

APC

A

tumor suppressor: colorectal carcinoma

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16
Q

WT1

A

tumor suppressor: Wilm’s tumor

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17
Q

NF1

A

tumor suppressor: neurofibromatosis type 1

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18
Q

NF2

A

tumor suppressor: neurofibromatosis type 2

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19
Q

DPC

A

tumor suppressor: pancreatic cancer

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20
Q

DCC

A

tumor suppressor: colon cancer

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21
Q

PSA

A

tumor marker: prostate carcinoma screening. also high in BPH and prostatitis.

22
Q

prostatic acid phosphatase

A

tumor marker: prostate carcinoma

23
Q

CEA (carcinoembryonic antigen)

A

tumor marker: CRC, panc, gastric, breast, thyroid medullary

24
Q

alpha-fetoprotein

A

tumor marker: HCC, non-seminoma germ cell tumor of testis and ovary

25
Q

beta-hCG

A

tumor marker: Hydatidiform moles, Choriocarcinoma, Gestational trophoblast tumor

26
Q

CA-125

A

tumor marker: ovarian, malignant epith tumor

27
Q

S-100

A

tumor marker: melanoma, neural tumor, schwannoma

28
Q

alkaline phosphatase

A

tumor marker: mets to bone, obstructive biliary disease, Paget disease of bone

29
Q

bombesin

A

tumor marker: neuroblastoma, lung cancer, gastric cancer

30
Q

TRAP (tartrate-resistant acid phosphatase)

A

tumor marker: hairy cell leukemia (B cells)

31
Q

CA-19-9

A

tumor marker: pancreatic adenocarcinoma

32
Q

calcitonin

A

thyroid medullary carcinoma

33
Q

HTLV-1

A

microbe: adult T cell leukemia/lymphoma

34
Q

HBV, HCV

A

microbe: hepatocellular carcinoma

35
Q

EBV

A

microbe: burkitt lymphoma, hodgkin lymphoma, nasopharyngeal carcinoma

36
Q

HPV

A

microbe: cervical carcinoma (type 16, 18), penile/anal carcinoma

37
Q

HHV-8

A

microbe: Kaposi sarcoma, body cavity fluid B cell lymphoma

38
Q

HIV

A

microbe: primary CNS lymphoma

39
Q

H.pylori

A

microbe: gastric adenocarcinoma and lymphoma

40
Q

Schistosoma haematobium

A

microbe: SCC of transitional epith (bladder)

41
Q

aflatoxin (derived from aspergillus)

A

toxin: HCC

42
Q

vinyl chloride

A

toxin: angiosarcoma - liver

43
Q

CCL4

A

toxin: centrilobular necrosis and fatty change - liver

44
Q

nitrosamines (smoked foods)

A

toxin: gastric cancer

45
Q

cigarette smoke

A 
toxin: 
SCC larynx
SCC and small cell LUNG
renal cell carcinoma
transitional cell carcinoma
46
Q

asbestos

A

toxin: mesothelioma and bronchogenic carcinoma

47
Q

arsenic

A

toxin: SCC skin; angiosarcoma liver

48
Q

naphthalene (aniline) dyes

A

toxin: transitional cell carcinoma of bladder

49
Q

alkylating agents

A

toxin: leukemia

50
Q

ionizing radiation: nuclear reactor accidents, radiotherapy

A

AML, CML, papillary carcinoma of thyroid

51
Q

non-ionizing radiation: UVB sunlight

A

all skin cancers - SCC, basal cell, melanoma

Pathology (10 decks)

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