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CC2Lec VII-II > Tumor Markers > Flashcards

Tumor Markers Flashcards

1
Q

What are the 5 types of tumor markers?

A 
Enzyme
Serum protein
Endocrine
Carbohydrate and cancer antigen
Receptor
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2
Q

PSA Tumor type, clinical importance, method, sample

A

Prostate cancer
prostate cancer screening/therapy monitoring/recurrence
Immunoassay
Serum

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3
Q

Lactate Dehydrogenase TCMS

A

Hematologic malignancies
Prognostic Indicator, elevated non specifically in numerous CA
Immunoassay
Serum

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4
Q

ALP TCMS

A

Metastatic bone CA, hepatocellular CA, osteosarcoma, lymphoma, leukemia
Determination of liver and bone involvement
Immunoassay
Serum

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5
Q

Neuron Specific Enolase

A

Neuroendocrine Tumors
Prognostic indicator and monitoring disease
Radioimmunoassay and immunohistochemistry
Serum

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6
Q

Serum M Protein TCMS

A

Plasma cell dyscrasias
Diagnosis and therapeutic monitoring
Electrophoresis, SPE, IFE
Serum

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7
Q

Serum Free Light Chains

A

Plasma Cell Dyscarsias
Diagnosis and therapeutic monitoring
Immunoassay
Serum

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8
Q

Beta 2 Microglobulin

A

Hematologic malignancies
Prognostic indicator and lymph proliferative disorders
Immunoassay
Serum

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9
Q

ACTH TCMS

A

Pituitary adenoma, ectopic ACTH producing tumor
Ectopic ACTH producing tumor
Immunoassay
Serum

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10
Q

ADH

A

Posterior pituitary tumors
SIAH syndrome or inappropriate ADH
Immunoassay
Serum

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11
Q

C Peptide

A

Insulin secreting tumor
Insulinoma
Immunoassay and ELISA
serum

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12
Q

Calcitonin

A

Medullary Thyroid Carcinoma
Monitoring recurrence of MTC
Immunoassay
Serum

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13
Q

Chromagranin A

A

Pheochromocytoma, neuroblastoma, carcinoid tumors, small lung cancers
Diagnosis of above
Immunoassay
Serum

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14
Q

Cortisol

A

Adrenal tumors
Cushing syndrome and adrenal adenoma
Immunoassay
Serum or Urine

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15
Q

Gastrin

A

Neuroendocrine Tumor
Prognostic for lymph proli disease
Immunoassay
Serum

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16
Q

Found on all surface of nucleated cells

A

Beta 2 Microglobulin

17
Q

AFP

A

Abundant carcinoembryonic serum protein

Increase in hepatocellular CA and germ cell tumor

18
Q

During the period of growth, AFP?

A

Decreases

19
Q

AFP peaks at ? The concentration of albumin at ?

A

1/10, 30 weeks gestation

20
Q

Clinical Application of AFP

A

Hepatocellular cancer or Hepatoma

Testicular CA

21
Q

Directly forms from malignant germ cells

A

Seminomatous tumor

22
Q

Differentiate into embryonal CA, teratoma, choriocarcinoma, and yolk sac tumors

A

Nonseminomatous tumor

23
Q

Yolk sac tumor
Choriocarcinoma
Teratoma
Embryonal CA

Afp and hcg differentiate

A

Up afp, hcg no
No afp, hcg up
No afp, hcg no
Up afp, hcg posi or nega

24
Q

CA125

A

Ovarian Cancer

25
Q

CEA

A

Marker for colorectal CA

Utilized in combination with histology and TNM staging system

26
Q

hCG, secreted by

A

Trophoblasts to maintain corpus luteum

27
Q

hCG is increased in

A

1st trimester

28
Q

Prognostic indicator of Ovarian Cancer

A

hCG

29
Q

Diagnostic marker for testicular CA

A

hCG

30
Q

Breast and Ovarian Cancer

A

BRCA 1

31
Q

Ovarian Cancer

A

CA 125

32
Q

Breast Cancer

A

CA 15-3

33
Q

Medullary Thyroid Cancer

A

Calcitonin

34
Q

CA 19-9

A

Gastric, pancreatic, colorectal CA

35
Q

Gastric and Pancreatic

A

CA 50

36
Q

Small cell lung CA

A

Ck 1

37
Q

Hepatoma

A

Estrogen Receptor

38
Q

Another breast cancer tumor marker

A

HER-2/neu

39
Q

Urinary bladder CA

A

Nuclear Matrix Protein

CC2Lec VII-II (4 decks)

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