Tumor Lysis Syndrome

Question 1

What are some of the metabolic derangements seen in TLS ?

Answer 1

Hyperuricemia
Hypocalcemia
Hyperkalemia
Hyperphosphatemia,

Question 2

Name some complications of TLS

Answer 2

AKI
Acidosis
Hypotension

Question 3

How do you manage patients at intermediate risk of TLS ?

Answer 3

Hydration
Allopurinol
Electrolytes monitoring

Question 4

How do you manage patients at high risk of TLS ?

Answer 4

Hydration
Rasburicase
Electrolytes monitoring

Question 5

Is there any benefit for urine alkalization in patients with TLS?

Answer 5

There is no clear benefit for alkalization of urine in increasing urine excretion of uric acid