Hypercalcemia Of Malignancy Flashcards
1
Q
Give examples of cancers that may be associated with HCM
A
myeloma
Head and neck cancer
Lung, breast and kidney cancer
2
Q
What are some of the mechanisms for HCM
A
osteolytic bone metastasis
paraneoplastic production of PHrPTH by localized tumors without widespread bone metastasis
Overproduction of 1,25 Vitamin D
3
Q
Name some symptoms of HCM
A
Nausea, vomiting, altered mental status, constipation, polyuria, polydipsia, fatigue
4
Q
What are some of the treatment modalities of HCM
A
Isotonic saline volume expansion
Lasix may be use after giving IVF in patients with heart failure and CKD
Calcitonin
Biphoisphonates
Denosumab in patients that did not respond to zoledronic acid
5
Q
What is the most appropriate treatment of HCM
A
Treatment of the underlying malignancy
