Hematopoietic stem cells and their disorders Flashcards
1
Q
What are the hematologic abnormalities seen in Aplastic anemia?
A
Anemia
Neutropenia
Thrombocytopenia
2
Q
What are some causes of aplastic anemia?
A
Autoimmunity
Infections
Toxin
Medications such as beta- lactic, sulfonamides,NSAIDs, gold, anticonvulsants, anti thyroid
3
Q
What are the options of treatment in AA?
A
Stem cell transplantation
Antithymocyte globulin
Cyclosporine
Prednisone
4
Q
What is cyclical neutropenia?
A
It is a rare congenital condition in which neutrophil counts decrease every 2 to 5 weeks. The neutrophil count can get low enough that patients develop recurrent infections every 2 to 5 weeks.
5
Q
What is Felty syndrome?
A
Neutropenia, Rheumatoid arthritis and splenomegaly