Hematopoietic stem cells and their disorders Flashcards

1
Q

What are the hematologic abnormalities seen in Aplastic anemia?

A

Anemia
Neutropenia
Thrombocytopenia

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2
Q

What are some causes of aplastic anemia?

A

Autoimmunity
Infections
Toxin
Medications such as beta- lactic, sulfonamides,NSAIDs, gold, anticonvulsants, anti thyroid

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3
Q

What are the options of treatment in AA?

A

Stem cell transplantation
Antithymocyte globulin
Cyclosporine
Prednisone

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4
Q

What is cyclical neutropenia?

A

It is a rare congenital condition in which neutrophil counts decrease every 2 to 5 weeks. The neutrophil count can get low enough that patients develop recurrent infections every 2 to 5 weeks.

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5
Q

What is Felty syndrome?

A

Neutropenia, Rheumatoid arthritis and splenomegaly

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