Tumor Lysis Syndrome

Question 1

What is the recommended daily hydration for patients?

Answer 1

3000 mL/m² per day of normal or 1/2 normal saline

Hydration is crucial for managing certain medical conditions effectively.

Question 2

What is the dosage of allopurinol for patients?

Answer 2

300 mg/m² per day

Allopurinol is used to manage uric acid levels.

Question 3

What laboratory values should be monitored every 6-12 hours?

Answer 3

Serum chemistry, specifically:
* Serum electrolytes
* Creatinine
* Calcium
* Phosphate
* Uric acid

Regular monitoring helps in timely intervention.

Question 4

What serum uric acid or crea level indicates treatment initiation after 24-48 hours?

Answer 4

Serum uric acid >8.0 mg/dL
Serum creatinine >1.6mg/dL

High uric acid levels can lead to complications.

Question 5

What serum uric acid L and creatinine indicates starting chemo and serum chemistry monitoring?

Answer 5

serum uric acid is <8.0 mg/dL and creatinine is <1.6 mg/dL

Elevated creatinine levels signify possible renal impairment.

Question 6

What should be done if serum uric acid is <8.0 mg/dL and creatinine is <1.6 mg/dL?

Answer 6

Start Chemotherapy
Monitor K, uric acid, crea, phosphate, calcium every 6 to 12h

Question 7

Uric acid > 8 and crea > 1.6 mg/dl,
Correct treatable renal failure

What is the initial treatment for correctable renal failure?

Answer 7

Correct the obstruction

Addressing the underlying cause is essential.

Question 8

serum uric acid is > 8.0 mg/dL and creatinine is > 1.6 mg/dL

What is the dosage of recombinant urate oxidase for treatment?

Answer 8

0.2 mg/kg IV daily

This treatment helps reduce uric acid levels.

Question 9

When should chemotherapy be delayed or dialysis started?

Answer 9

If:
* Serum K* >6.0 meg/L
* Serum uric acid >10 mg/dL
* Serum creatinine >10 mg/dL
* Serum phosphate >10 mg/dL or increasing
* Symptomatic hypocalcemia present

These conditions indicate severe metabolic derangements.

Question 10

What alternative medication should be used in case of allopurinol allergy or renal failure?

Answer 10

Febuxostat

Febuxostat is an alternative urate-lowering therapy.

Question 11

True or False: Serum phosphate levels must be monitored in patients undergoing treatment.

Answer 11

True

Phosphate levels are critical in assessing renal function and treatment response.

Question 12

Xx

Answer 12

.