Lung ca Histology - Pathologic - IHC

Question 1

What type of carcinoma shows glandular differentiation or mucin production?

Answer 1

Adenocarcinoma

Adenocarcinoma may exhibit acinar, papillary, lepidic, or solid features or a mixture of these patterns.

Question 2

What are the characteristics of squamous cell carcinoma?

Answer 2

Show keratinization and/or intercellular bridges

Squamous cell carcinoma arises from bronchial epithelium.

Question 3

What defines small cell carcinoma?

Answer 3

Small cells with scant cytoplasm, ill-defined cell borders, finely granular nuclear chromatin, absent or inconspicuous nucleoli, and high mitotic count

These features indicate a high level of cell division.

Question 4

What are the characteristics of large cell carcinoma?

Answer 4

Lack the cytologic and architectural features of small-cell, glandular, or squamous differentiation

This distinguishes large cell carcinoma from other types.

Question 5

Fill in the blank: A positive marker for adenocarcinoma is _______.

Answer 5

Napsin A

Napsin A shows positivity in 90% of adenocarcinoma cases.

Question 6

What percentage of cases show TTF1 positivity in adenocarcinoma?

Answer 6

> 70%

TTF1 is a key marker for identifying adenocarcinoma.

Question 7

What does a positive P40 or p63 indicate?

Answer 7

+: P40, p63

These markers are associated with squamous cell carcinoma.

Question 8

Fill in the blank: A negative marker for adenocarcinoma is _______.

Answer 8

CK20

CK20 is typically negative in squamous carcinoma cases.

Question 9

Which markers are positive in small cell carcinoma?

Answer 9

• NSE
• CGS6
• NCAM
• synaptophysin
• chromogranin
• Leu7
• TTF1

And negative for Napsin A

These markers help in the diagnosis of small cell carcinoma.

Question 10

Squamous Cell Ca IHC

Answer 10

(+) P40, p63
(-): Napsin A, TTF1, CK7, CK20