Tuesday - neoplastics and hormone drugs - Trach

Question 1

GnRH receptor agonists
effect?
used for?

Answer 1

Goserelin
Leuprolide
if given constantly, inhibit FSH and LH –> decrease testosterone. simulate imedeately

prostate cnacer

Question 2

GnRH antagonist
effect
used for?

Answer 2

Degarelix
decrease FSH and LH –>
reduces testosterone

prostate cancer

Question 3

5alpha reductase inhibitor
reaction is stops
effect

Answer 3

finasteride, also dutasteride
testosterone to DHT

DHT increases prostate, so finasteride inhibits that.

also used for hair loss

Question 4

17 alpha reductase inhibitor

effect

Answer 4

abiraterone

blocks testosterone synthesis

Question 5

testosterone antagonists

effect

Answer 5

bicalutamide, flutamide

chemical castration

Question 6

DHT agonist

Answer 6

oxandraline

Question 7

Prostate cancer tx

Answer 7

GnRH agonist (goserelin)
also anti androgen (bicalutamide) for a few weeks to prevent to initial stimulation

Question 8

drug that blocks pregnenalone synthesis

Answer 8

aminoglutethimide

Question 9

drug MOAs used for breast cancer

Answer 9

GnRH a(nt)agonists to block FSH and LH
aromatase inhibitors to block estrogen production
estrogen blockers

anthracyclines - 5FU, doxo, cyclophosphamide

Question 10

Aromatase inhibitors

Answer 10

anastrazole

exemestane - irreversable

Question 11

Estrogen modulators

Answer 11

tamoxifen, raloxifene, tormifene

antag at breats

Question 12

estrogen effects at
breast
uterus
bone

Answer 12

prolif
- tamox is a partial ag (antag effect)

prolif
- tamoxifen is an agonist here, which isn’t preferable

anti-resorptive
- we want drugs to be agnoists at bone to promote bone strength