Tubular K Transport Flashcards
1
Q
what factors increase K secretion from principal cells?
A
- distal nephron flow rate- high flow = more K secreted
- increased Na in lumen- more Na absorption = more K secretion
- alkalosis- increase H = less K uptake
- aldosterone
- high K diet–>more aldosterone
2
Q
what causes hyperkalemia?
A
renal disease
hypoaldosteronism
acidosis
rhabdomyelosis
3
Q
what happens during diabetic ketoacidosis?
A
increased ECF K concentration but decreased ICF K concentration
normally, would want to promote K excretion, but here that would be bad
4
Q
why is K secretion not affected in hypovolemic states?
A
aldosterone is increased but angiotensin II is also activated which inhibits apical channels of principal cells
5
Q
why is K secretion affected in hyperkalemia?
A
only aldosterone is acting on principal cells, which promotes k secretion
