Tuberculosis

Question 1

Which bacteria is the commonest cause of TB?

Answer 1

Mycobacterium tuberculosis

Question 2

What is the primary test for TB?

Answer 2

PCR

Question 3

TB involves non-caseating necrosis. True/False?

Answer 3

False
It is caseating

Question 4

What is interferon gamma testing re TB?

Answer 4

Sample of blood + mixing it with antigens from TB bacteria.
Previous contact with TB= WBC will release interferon-gamma as part of an immune response.

Question 5

Which 4 drugs are used for TB?

Answer 5

Rifampicin
Isoniazide
Pyrazinamide
Ethambutol

Question 6

Start of with 4 months on RI, then 2 months on PE. True/False?

Answer 6

False
2 months on RIPE, then 4 months on RI

Question 7

If patient has TB affecting CNS, what is the treatment course?

Answer 7

2 months on RIPE, then 10 months on RI

Question 8

List some adverse reactions of Rifampicin

Answer 8

Hepatitis
Orange-red urine
Flu syndrome

Question 9

List some adverse reactions of Isoniazide

Answer 9

Hepatitis
Peripheral neuropathy

Question 10

List some adverse reactions of Pyrazinamide

Answer 10

Hepatitis
Anorexia, vomiting
Hyperuricaemia (resulting in gout)

Question 11

List some adverse reactions of Ethambutol

Answer 11

Colour blindness, developing into blindness
Arthralgia

Question 12

What proportion of the world population is affected by TB?

Answer 12

1/3

Question 13

Which components make up the necrosis in TB?

Answer 13

Epitheloid cells and Langhan’s giant cells, causing formation of Ghon focus

Question 14

When might the Mantoux/tuberculin skin test for TB be false negative?

Answer 14

If patient has had a BCG vaccination