TUBERCOLOSIS

Question 1

CHARACTERISTICS OF TUBERCULOSIS DISEASE

Answer 1

• 2ND LEADING cause of death worldwide due to microorganisms
• caused by Mycobacterium Tuberculosis
• intracellular infection, slow growth, dormant microorganism
• MDR-TB, multi-drug resistant TB, resistant to isoniazid and rifampicin

Question 2

COMPOUND DRUG THERAPY FOR TB

Answer 2

• 2 MONTHS isoniazid+rifampicin+pyrazinamide +/- ethambutol
• followed by 4 months of isoniazid and rifampicin

longer treatment if bone or joint involvement or resistance

Question 3

CHARACTERISTICS OF ISONIAZID

Answer 3

• MOA inhibition of synthesis of mycolic acids, essential elements of mycobacterial walls
• limited use to TB
• bacteriostatic on resting organism
• bactericidal on active growing bacilli
• s/e dose-dependent . REDUCES METABOLISM OF ANTI-EPILEPTIC AGENTS