DYSLIPIDEMIA

Question 1

ATHEROSCLEROSIS PROCESS

Answer 1

• damage of endithelial cells and leakage of thight junction
• inflammatory response and accumulation of lipids and fibrous elements in large and medium arteries.
• reduction of vessel lumen and risk or MI, stroke and PVD

Question 2

what happens to the endothelial cells once the endothelium is damaged?

Answer 2

the endothelial cells recruit monocyte and they both release radicals to attract macrophages

Question 3

WHAT is THE ROLE OF LDL IN ATHEROSCLEROTIC PLAQUE FORMATION

Answer 3

LDL travel into the vessels and they are taken by the macrophages in the damaged endothelium, that digest them and deposit them into the vessel, foam cells release cytokines which stimulate the smooth muscle cells to create connective tissue to stop the lesion. a fibrous cap is created.

Question 4

VLDL transport TGs and _____ from ____ tract to the tissue where TGs are changed into FFA and glycerol and stored or used from the cell

LDL, high content _______ ________ taken from ____ and ______ and travels in the blood stream

HDL carries _________ from the bloodstream to the _____ where it can be removed from the body

Answer 4

cholesterol, GI, cholesterol lipoprotein, liver tissues, high-density cholesterol lipoprotein, liver

Question 5

STATINS NAC

Answer 5

• NATURE. HMC- CoA REDUCTASE INHIBITORS which from acetyl-CoA to 3-HMG-CoA forms mevalonic acid precursor of cholesterol.
• MOA. inhibit cholesterol synthesis in the liver
• C. ⤓hepatic cholesterol synthesis, ⇡LDL receptor synthesis, ⇡LDL clearance from plasma, ⇣LDL in the plasma
• DRUGS. simvastatin ( specific reversible inhibitors), atorvastatin (irreversible inhibitor) well-tolerated and low S/E.