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NMED 291 - Clinical Procedures 2 > TU Imaging > Flashcards

TU Imaging Flashcards

1
Q

three NE tumors

A

pheochromocytoma, neuroblastoma, paraganglioma

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2
Q

paraganglioma

A

pheochromocytoma occurring by the adrenal

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3
Q

pheochromocytoma

A

benign and in the adrenal medulla

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4
Q

neuroblastoma

A

malignant and typically, when it presents itself, mets has already occurred
accounts for 10% of all childhood ca

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5
Q

dose of 123I-mIBG

A

typically, 370 MBq

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6
Q

dose of 131I-mIBG

A

40-80 MBq

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7
Q

peds dose

A

5.2 MBq/kg, max 370 MBq

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8
Q

mechanism of uptake for 123I/131I-mIBG

A

taken up in chromaffin cells by active transport

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9
Q

123I/131I-mIBG is an analogue of?

A

norepinephrine

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10
Q

purpose of pretreating pts with SSKI?

A

decreases thyroid uptake

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11
Q

injection to imaging time with 123I-mIBG

A

24 hrs

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12
Q

injection to imaging time for 131I-mIBG

A

24 and 48 hrs

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13
Q

half life for 131I

A

8 days

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14
Q

half-life for 123I

A

13.2 hrs

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15
Q

what collimators are used?

A

MEAP/HEAP

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16
Q

energy for 123I

A

159 keV, no beta emission

17
Q

energy for 131I

A

364 keV, with beta emission

18
Q

where are neuroblastomas usually found?

A

1/3 in adrenals
1/3 in abdomen
1/5 in chest

19
Q

NE have high density of SSTR. which subtypes do the analog of somatostatin labelled with 111In have an affinity for?

A

subtype 2 and 5

20
Q

carcinoid syndrome

A

symptoms due to the release of too much serotonin

21
Q

carcinoid crisis

A

severe case of flushing, low BP, difficulty breathing and irregular heart beat

22
Q

111In-Octreoscan/Octreotide is an analogue of?

A

peptide somatostatin

23
Q

when do we image when using 111In-octreotide?

A

at 4-6 hrs, 24hrs and sometimes 48 hrs if requested

24
Q

what are the energies that 111In has?

A

173 and 247 keV

25
Q

mIBG is used for adrenal NETs only. T/F

A

true

26
Q

what is an alternative somatostatin analogue used? what subtype does it bind to?

A

68Ga-dotatate
bings to subtype 2

27
Q

why 68Ga PET scans?

A
  • scans can be completed in 2 hrs
  • radiation dose is less with 68Ga

NMED 291 - Clinical Procedures 2 (11 decks)

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