TS3

Question 1

What does the safety of blood transfusion depend on?

Answer 1

Meticulous attention to detail at each stage leading to and during transfusion

Question 2

What causes more than 50% of fatalities during a blood transfusion?

Answer 2

Immediate haemolytic transfusion reactions

Question 3

Other than haemolytic transfusion reactions, what causes the remained of fatalities during a blood transfusion?

Answer 3

Post-transfusion hepatitis

Question 4

What pre-transfusion compatibility tests can be performed?

Answer 4

Blood Grouping

Antibody Screening

Question 5

What is the purpose of blood grouping?

Answer 5

ABO & RhD groups determined

Question 6

What is the purpose of Antibody screening?

Answer 6

Patient’s serum screened for atypical antibodies which may cause significant reduction in survival of transfused red cells

Question 7

How is antibody screening performed?

Answer 7

Patient’s serum tested against red cells from at least two group O donors expressing a wide range of red cell antigens for detection of IgM red cell alloantibodies
and IgG antibodies

Question 8

If antibody screening comes back positive, what needs to be done?

Answer 8

Blood group specificity of the antibody should

be determined using a panel of typed red cells