Trophoblastic Neoplasia and Molar Pregnancies Flashcards
This type of molar pregnancy is from one egg with no DNA fertilized by 1-2 sperm, has high risk of becoming malignant, there will be no fetal heart rate on US?
Complete
This type of molar pregnancy is abnormal tissue + a fetus, is an egg fertilized by 2 sperm, and usually results in spontaneous abortion?
Partial molar pregnancy
This molar pregnancy type has 46XX with all chromosome from dad?
Complete
This molar pregnancy has 69 XXX or 69 XYY, & the fetus is always malformed and not viable?
Partial
This type of molar pregnancy has a HIGH hCG?
Complete
This molar pregnancy has a slightly increased hCG & the fetus is seen on US?
Partial
What is the treatment for both types of molar pregnancies?
E&C now to reduce cancer risk
What is the follow up procedure for monitoring hCG after a molar pregnancy removal?
Monitor hCG for 3 weeks in a row
Then monitor monthly
What is the indication of a consistently high hCG after a E&C procedure is completed
cancer
How long should people wait to get pregnant after having a molar pregnancy?
1 year
What is the main risk for having a molar pregnancy?
being <20 y/o or >35y/o
What is an invasive mole?
A malignancy from a molar pregnancy
What are the 3 signs of an invasive mole?
- Persistent abnormal uterine bleeding
- boggy uterus
- Hyperemesis
If hGC is detectable 6 months post evacuation, what DX is likely
invasive mole
What is the diagnostic test for invasive mole and what does it show?
Ultra sound
Show high vascular flow
WHat is the treatment for invasive mole?
Methotrexate as chemotherapy or hysterectomy
What is a HIGHLY malignant epithelial tumor from any type of pregnancy even abortion, ectopic, or molar?
Choriocarcinoma
Presentation; abnormal uterine bleeding, pelvic pain, pressure in pelvis; Ultrasound shows single mass distending from the uterus with necrosis and hemorrhage?
Choriocarcinoma
This cancer that results from a pregnancy is chemotherapy resistant & can happen years after pregnancy?
Placental site trophoblastic tumor
What is the treatment for choriocarcinoma?
Methotrexate and surgical resection of affected area
An hCG over what level is indicative of a molar pregnancy?
> 100,000
