Trigger 7: TBI associated disorders Flashcards
chronic traumatic encephalopathy
a progressive degenerative disease, which starts which memory loss and mood swings and then difficulty concentrating… progressing into demetia
is there a cure for CTE
no
CTE
chronic traumatic encephalopathy
what other diseases which have been given different names are also CTE
boxing demential and punch drunk syndrome
boxing dementia and punch drunk syndrome are
chronic traumatic encephalopathy
cause of CTE
repetitive mild TBI
who does CTE effect
athletes (boxing, rugby football etc) and veterance
symptoms of CTE
Memory loss, depression, suicidal thought, explosive or aggressive behaviour, trouble walking and speaking
pathology of chronic traumatic encephalopathy
Tau protein tangles first accumulate in the brain cortex. Tau collects around blood vessels and deep in cortical sulci of the brain (decreased surface area of actual brain)
treatment of CTE
none
evidence of links between head trauma and long-term degenerative disease e.g. alzheimers
both have hyper phosphorylated Tau proteins associate with dementias –> brains look similar e.g. lose surface area
who are at higher risk of CTE and demential
those with Apolipoprotein E genotypes (APoE)
demential pugilistica
boxing demential
boxing dementia associated with
- Associated with slurred speech
- Memory impairment and Parkinson-like syndrome
- Punch-drunk syndrome
- Thought to be the same as CTE
describe the time scale of dementia caused by TBI (rate of cognitive decline)
1) head injury
2) acute effects of TBI
3) recovery- but loss of functional reserve
4) functional reserve decreases to threshold for dementia
