Tricyclic Sntidepressant Flashcards
1
Q
Name an example
A
Amitripyline
2
Q
Uses
A
Moderate to severe depression when ssri failed to work
Not licenced for but can see improvement with neuropathic pain
3
Q
Mechanism
A
Inhibits 5ht (serAtonin) reuptske and noradrenaline in the synaptic cleft increasing AvAilbility for transmission.
Can impact other receptors (block) therefore limited clinical use
4
Q
Side effects
A
Dry mouth
Visual disturbances - blurred vision
Constipation
Hypotension
Prolonged QT
Hallucinations
Mania
Convulsions
Breast changes
Sexual dysfunction
Hypotension
Stomatitis
Restlessness
5
Q
Contraindicated
A
Elderly Cvd disease Epilepsy Intracranial pressure Constipation
6
Q
Interactions
A
MAOI as this works to increase serotonin and noradrenaline in the cleft
7
Q
End of treatment factor ?
A
Wean off
Sudden withdraw can cause sleep and gastro disturbances and influenza like symptoms
