Tricyclic antidepressants Flashcards
1
Q
Tricyclic antidepressant examples?
A
Amitryptiline, dosulepin, imipramide
2
Q
Main indications?
A
Depressive illness
- Used 3rd/4th line due to toxicity in overdose + side-effects
Sometimes used in chronic pain management
3
Q
Mechanism of action?
A
Blocks re-uptake of monoamines (mainly noradrenaline and 5-HT) into presynaptic terminals.
4
Q
Contraindications and cautions?
A
Contraindicated in manic phase of bipolar disorder.
5
Q
Adverse effects?
A
Anti-cholinergic
- Blurred vision
- Dry mouth
- Constipation
- Urinary retention
Sedation
Weight gain
6
Q
Administration of medication?
A
PO (orally)
