Treatments For Sz - Drug Therapy Flashcards
what are the treatments for schizophrenia
- drug therapy
- CBT (psychological)
- family therapy (psychological)
what are the two anti - psychotic drugs in drug therapy?
- typical anti psychotics ; 1st gen
- atypical anti psychotic ; 2nd gen
what is the order of these anti - psychotic drugs that patients should take them in?
typical anti-psychotics are used more often, if symptoms do not improve then atypical antipsychotics may be used.
what is an example of a typical anti-psychotic drug?
chlorpromazine
define typical antipsychotics (AO1 - 1st point)
- 1st gen antispychotics; chloropromazine are dopamine antagonists, they reduce levels of dopamine activity in the brain
how does chloropromazine work? (AO1 - 2nd point)
- binds to D2 receptors on post synaptic neuron in brain, reducing activity levels of dopamine
what is the result of typical antispychotics - chloropromazine?
(AO1 - 3rd point)
- reduces positive symptoms of sz such as hallucinations
- they are also used as a sedative and can be used to calm patients
For an 8 mark essay would you use typical antipsychotics for AO1 for atypical antispsychotics?
Typical antispychotics - chloropromazine
What is an example of an atypical antispychotic drug?
Clozapine
define atypical antipsychotics (AO1 - 1st point)
Second gen - atypical antipsychotics act on dopamine AND seretonin
how does clozapine act on dopamine?
(AO1 - 2nd point)
- clozapine also binds to D2 receptor sites on the post synaptic neuron
- this reduces positive symptoms such as hallucinations
How does clozapine act on seretonin?
- acts as an agonist on seretonin receptor sites to increase levels of seretonin
- this reduces neg symptoms of sz such as lack of emotions as it helps to improve mood and reduce dep and anx in patients
Summarise typical antipsychotics
Typical antipsychotics - chloropromazine
Reduces dopamine activity - anatagonist
Blocks D2 receptors in the brain - lower dopamine brain activity
Reduce positive symptoms - hallucinations and delusions
Summarise atypical antipsychotics
Atypical antipsychotics - clozapine
Reduces dopamine activity - antagonist
Increases seretonin activity - agonist
Binds to dopamine receptors
Acts on seretonin receptors
Reduces negative symptoms - lack of emotion and low mood
what are the three PEELS to evaluate drug therapy?
RTS - effectiveness of drug therapy
strength - requires less motivation than CBT
weakness - has negative side effects