Treatments for OA Flashcards
What are the risk factors for OA
- genetic predisposition
- hereditary factors
- age
- joint injury previously
- Gender
- joint immobilization
- obesity
- overuse of the joint
- high intensity sport
describe the viscous cycle of OA
- There is altered mechanical loading n the cartilage, bone and ligaments
- this causes proteolytic destruction of cartilage matrix and chondrocyte death
- this leads to remodelling of the bone osteophytes, angiogenesis, and subchondral sclerosis
- there is abnormal synovial fluid and thus reduced viscosity
- leaving to synovial inflammation and angiongesi
- peripheral and central sensitisation and nociceptor activation causing pain
- this leads to a reduced in exercise, muscle weakness which leads to altered mechanical loading of cartilage, ligaments and bone
What are the health outcomes of OA
- Joint destruction
- Severe pain
- loss of joint function
- disability
- social isolation
- depression
- reduced quality of life
What is OA
OA is a metabolically active repair process and causes localised loss of cartilage and remodelling of adjacent bone
- results in varying degrees of functional limitation and a reduction in quality of life
what are the areas that are commonly affected by osteoarthritis
- knees
- Hips
- Small hand joints
- knees and hips as they are weight bearing joints
describe characteristics of OA
- not always caused by ageing
- not always progressive (some people get it worse than others)
What are the Clinical symptoms of OA
- Joint pain (with use)
- morning stiffness lasting less than 30 minutes
- joint instability or buckling
- Loss of function
- Crepitus (creaking or cracking of the joint - marker that cartilage is lost or it is cracked) on motion
What are the clinical signs of OA
- Bony enlargement at affected joints
- limited range of motion
- muscle atrophy/weakness
- Mal-alignment and or joint deformity
- crepitus on motion
What is crepitus a marker for
creaking or cracking of the joint - marker that cartilage is lost or it is cracked
How should you educate someone with OA
- offer accurate verbal and written information
- patient centred
- individualised self management strategies agreed between patient and healthcare professionals
what are some lifestyle changes that people with OA can make
Exercise – swimming
Weight loss if obese
Use of suitable footwear
Walking at an appropriate speed and pacing
describe the OA pyramid of treatment
- every one is given information and advice
- everyone is given self help ideas such as lifestyle changes
- then you have NSAIDs, physiotherapy, occupational therapy
- advanced - non surgical interventions, injections
- surgery - total joint replacement or partial joint replacement
- surgery joint preserving
what is the non pharmacological care that can be given to patients with OA
Exercise – core treatment
- Local muscle strengthening
- General aerobic fitness
- Weight loss
Transcutaneous electrical nerve stimulation (TENS) as an adjunct for pain relief
Aids and devices
- Orthopaedic insoles
- Walking stick
lifestyle changes
diet
Thermotherapy
- use of local heat or cold
Nutriceuticals
- increase intake of omega 3 rich foods
- Chondroitin sulphate and glucosamine supplements – no longer recommended that they should be recommended or approved
what is better then changing just exercise
Exercise and diet
arthritis prevalence increased with
body weight - the more obese you are the higher the chance you have of getting OA
What are the oral analgesics that can be used for OA treatment
- paracetamol and/or topical NSAID
what happens when paracetamol and topic NSAIDS are not ineffective
- give oral NSAID or COX-2 inhibitor
- used at lowest effective dose for shortest possible period
- start with NSAID then go onto the COX-2 inhibitor such as celecoxib
- Co-prescribe with PPI due to the gastric problems caused
name an example of a COX -2 inhibitor
celecoxib
what happens when the oral NSAID and COX-2 inhibitor is not effective
- give intra-articular injections = corticosteroid injections
where does the topical NSAID go
concentrated into the synovial fluid so it gets into the joint where the pain is