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GI Week 2 & 3 > Treatments for IBD > Flashcards

Treatments for IBD Flashcards

1
Q

Sulfasalazine, Mesalamine, Olsalazine, and Balsalazide make up what drug class?

A

Aminosalicylate (5-ASA) drugs

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2
Q

Sulfasalazine, Olsalazine, and Balsalazide are all converted to?

A

Mesalamine

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3
Q

What is the MOA of the 5-ASA agents?

A

Inhibition of prostaglandin and leukotriene production via COX (cyclooxygenase) and LIPOX (lipoxygenase) pathways

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4
Q

5-ASA agents result in the reduction of chemotaxis of?

A

PMN and macrophage

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5
Q

All 5-ASA compounds are contraindicated in?

When is sulfasalazine additionally contraindicated?

A

1) ASA allergic patients

2) Sulfa allergic patients

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6
Q

Which 5-ASA agents is used only for maintenance of remission?

Which is used only for active UC?

A

1) Olsalazine

2) Balsalazide

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7
Q

What are the 5-ASA agents?

A

1) Sulfasalazine
2) Mesalamine
3) Olsalazine
4) Balsalazide

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8
Q

Adalimumab, Golimumab, Certolizumab and Infliximab make up what class of drugs?

A

TNF-α inhibitors

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9
Q

TNF-α binds to TNF receptors and mediates upregulation of what surface adhesion molecules for leukocyte adhesion?

A

1) VCAM-1
2) E-selectin
3) MAdCAM-1

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10
Q

What is the side effect for TNF-α inhibitors?

What should be done pre-therapy?

A

1) Increase risk of infection

2) TB testing

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11
Q

Which TNF-α inhibitors is used for moderate to severe UC and CD?

A

Adalimumab

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12
Q

Which TNF-α inhibitors is used for moderate to severe CD and severe UC?

A

Infliximab

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13
Q

Which TNF-α inhibitors is used for UC only?

A

Golimumab

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14
Q

Which TNF-α inhibitors is used for CD only?

A

Certolizumab

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15
Q

When are all TNF-α inhibitors and α-4 Integrin inhibitors used?

A

After inadequate response to 5-ASA

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16
Q

What is the dosing for Adalimumab?

What is the dosing for Infliximab?

What is the dosing for Golimumab?

What is the dosing for Certolizumab?

A

1) SQ every 2 weeks
2) IV every 8 weeks
3) SQ every 4 weeks
4) SQ every 4 weeks

17
Q

What are the TNF-α inhibitors?

A

1) Adalimumab
2) Golimumab
3) Infliximab

18
Q

Vedolizumab and Natalizumab makes up what class of drug?

A

α-4 Integrin Inhibitors

19
Q

Which α-4 Integrin inhibitors targets α4β7 so that is can’t go to its receptor MAdCAM-1?

Which targets α4β1 and α4β7 so that it can’t go to its receptor VCAM-1 and MAdCAM-1 respectively?

A

1) Vedolizumab

2) Natalizumab

20
Q

What side effects are seen with α-4 Integrin inhibitors?

A

1) Increased risk of infections

2) PML

21
Q

What is the indication for natalizumab?

What is the indication for vedolizumab?

A

1) CD

2) CD and UC

22
Q

What is the dosing for natalizumab?

What is the dosing for vedolizumab?

A

1) IV every 4 weeks

2) IV every 8 weeks

23
Q

What are the α-4 Integrin Inhibitors?

A

1) Vedolizumab

2) Natalizumab

24
Q

Ustekinumab makes up what class of drugs?

A

IL-12/23 Inhibitors

25
Q

What is the mechanism for IL-12/23 inhibitors?

A

Bind to P40-subunit of IL-12 & IL-23 blocking activation of naïve T cells and NK cells

26
Q

What is the side effect for Ustekinumab?

What should be done pre-therapy?

A

1) Increase risk of infection

2) TB testing

27
Q

What is IL-12/23 inhibitors indicated for?

A

UC and CD

28
Q

What is the dosing for IL-12/23 inhibitors?

A

SQ every 8 weeks

29
Q

Tofacitinib makes up what class of drugs?

A

Janus Kinase (JAK) Inhibitors

30
Q

Tofacitinib makes up what class of drugs?

A

Janus Kinase (JAK) Inhibitors

31
Q

What is the MOA of the JAK inhibitor?

A

Bind to and inhibit free-floating and bound JAK-1 and JAK-3

32
Q

What is Tofacitinib indicated for?

A

UC

33
Q

What is the JAK inhibitor?

A

Tofacitinib

34
Q

What are the agents for ulcerative colitis?

A

1) 5-ASA
2) Janus Kinase (JAK) Inhibitors
3) IL-12/23 Inhibitors
4) TNF-α Inhibitors
5) α-4 Integrin Inhibitors

35
Q

What are the agents for crohn’s disease?

A

1) IL-12/23 Inhibitors
2) TNF-α Inhibitors
3) α-4 Integrin Inhibitors

GI Week 2 & 3 (9 decks)

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