Treatment - Part 2 of 3 Flashcards
A leading hypothesis as to why atypical antipsychotic medications are less likely than typical neuroleptic agents to cause EPS is based one which of the following properties of atypical antipsychotics?
RAPID DISSOCIATION FROM D2 RECEPTORS
35 y/o pt is started on a trial of clozapine for treatment-refractory schizoaffective disorder. During the initial medication titration, pt complains of sedation and orthostatic hypotension as well as flu-like symptoms, but seems symptomatically improved. However after a dose increase from 150 to 200mg, pt develops a fever to 102 degrees, tachycardia to 130bpm, and an acute metal status change. CXR, urine studies, and blood culture are unremarkable. A CBC reveals a WBC of 11.4, with an elevated eosinophil percent of 7%. Which known toxic risk of clozapine is the most likely Dx?
MYOCARDITIS
A 30yo w. 5yo hx of Schizophrenia, prior failed Haldol and Risperidone trial, despite adherent to meds continues to have severe psychotic symptoms. Med recommendation at this time is..
CLOZAPINE
30 yo on Clozapine for treatment resistant schizophrenia presenting with dyspnea, orthostatic hypotension and HR 130bpm. Elevated Eosinophil , EKG with non-specific T wave changes. Further most likely test to guide treatment
TROPONIN LEVEL
What lab finding is most typically associated with NMS?
INCREASED CREATINE KINASE LEVELS
Appropriate management of neuroleptic malignant syndrome:
HYDRATION AND COOLING
Antipsychotics are associated with what?
DYSTONIA, POIKILOTHERMY, LIPID SOLUBILITY, AND LOWER SEIZURE THRESHOLD
Which of the following effects is the basis for dantrolene’s efficacy in the treatment of neuroleptic malignant syndrome (aka nms)?
SKELETAL MUSCLE RELAXANT
32 y/o pt with hx of schizoaffective d/o stable on clozapine is admitted to internal medicine service for a severe GI viral infection. Pt is confused, slow, appears visibly ill and tired. Pt c/o stiffness and there is some rigidity to the movements. What should be recommended?
DISCONTINUE CLOZAPINE
Which antipsychotic has least effect on prolactin?
CLOZAPINE
A slow titration of Clozapine is required to decrease the risk of:
SEIZURES
Which neuroleptic has the weakest affinity for the dopamine D2-like receptor?
CLOZAPINE
Clozapine clearance decreased by
CIMETIDINE
Which med is contra-indicated with clozapine?
CARBAMAZEPINE
Schizophrenic on haldol 5mg presents to ED “unable to see.” Appears distressed, writhing and moaning. States “I’m unable to stop looking up.” What is the best treatment?
ADMINISTER BENZTROPINE 1MG IV NOW
What manifestations is the most common side effect of conventional antipsychotic meds?
AKATHISIA
What antipsychotic medication would be the best choice to avoid motor symptoms in Parkinson’s disease?
CLOZAPINE
What antipsychotic medication is helpful in treating Tourette’s?
HALOPERIDOL
Pt develops feelings of restlessness, an inability to relax, jitteriness, pacing, and rapid alternation of sitting and standing shortly after being started on a low dose of haloperidol. Addition of what medications would be most effective in managing these symptoms?
ATENOLOL
The therapeutic effect of 2nd generation antipsychotics on negative symptoms of schizophrenia is thought to be related to the induction of expression in what area of the brain?
PREFRONTAL CORTEX
Psych MD orders quetiapine 50 mg for an 82 y/o nursing home pt w/ dementia who has become severely agitated. Soon after, the psychiatrist receives a call from a family member who is concerned about the “black box” warnings associated with antipsychotics in the elderly. Which of the following is the most accurate information the psychiatrist could give the family member regarding the potential safety risks of this medication? (x2)
ATYPICAL ANTIPSYCHOTICS INCREASE MORTALITY; THIS MUST BE BALANCED AGAINST ANY POTENTIAL BENEFIT
Blockade of dopamine receptors in tuberoinfundibular tracts results in breast enlargement, galactorrhea, impotence, and amenorrhea. Mechanism is increase of:
PROLACTIN
Correlation of plasma drug concentration with the clinical effectiveness is best established for which antipsychotics?
CLOZAPINE AND HALOPERIDOL
Acutely psychotic pt started on risperdal 2 mg qhs. Increased to 3 mg BID over next few days. Pt becomes increasingly agitated, restless, unable to stop pacing. Most appropriate intervention?
ADD PROPRANOLOL 10 MG TID
Psychotic pt given haldol, acute laryngospasm. In addition to intubation, give:
COGENTIN
Schizophrenic OD’d on antipsychotics, has EPS and urinary retention. Tx?
AMANTADINE
Pts over 65 y/o are less likely to tolerate higher doses of antipsychotics due to:
DECREASED HEPATIC METABOLISM
25 y/o pt is brought to the ED with a sudden onset of severe spasms of the neck and eyes deviated up and to the right. The pt has had a viral illness with nausea and vomiting and was given prochlorperazine yesterday. Which of the following meds would be most appropriate to prescribe for this patient?
DIPHENHYDRAMINE
A neonate has transient hyperreflexia, irritability, and tremors followed by a period of depressed interactive behavior and poor response to environmental stimuli. What did the childs mother use?
OLANZAPINE
In the Clinical Antipsychotic Trials of Intervention Effectiveness (CATIE) study, which medication was the most effective due to its low rate of discontinuation, high reduction in psychopathology, and longest time to discontinuation of treatment
OLANZAPINE
Patient started on clozapine for treatment-resistant schizophrenia has initial ANC of 2200/mm3. How frequently should you get a CBC with diff?
WEEKLY
greatest risk factor for developing akathisia? Male sex, younger age, rapid dose escalation, lower potency agents, positive symptoms
RAPID DOSE ESCALATION
Quetiapine is known to develop diabetes, if starting metformin, this is an example of what kind of prevention? (primary, secondary, tertiary or quaternary?)
TERTIARY
What psychotropic can cause a decrease in benzo plasma levels? (6x)
CARBAMAZEPINE
Which benzo accumulates with repeated administration, should be avoided in chronic renal failure, and most likely to accumulate with repeated dosing? (3x)
DIAZEPAM
Which of the following medications would be preferable for use in an anxious patient with pulmonary disease? (3x)
BUSPIRONE
If prescription benzo is necessary for a patient w/ severe hepatic dysfunction which of the following is most appropriate choice to avoid elevated serum levels. (2x)
LORAZEPAM
Which benzo is reliably absorbed given IM? (2x)
LORAZEPAM
Which of the following reverses the effects of benzodiazepines? (2X)
FLUMAZENIL
47 yo with well controlled epilepsy well controlled on monotherapy develops nausea, ataxia, and diplopia when treated with erythromycin. Which antiepileptic?
CARBAMAZEPINE
Decreases congenital malformations in women taking anti-epileptic medications
FOLIC ACID
The use of flumazenil for treating benzo OD is limited by …
THE RISK OF INDUCING WITHDRAWAL SEIZURES IN BENZO- DEPENDENT PTS
75 y/o pt with cirrhosis should be given which of the following meds:
TEMAZEPAM
False positive urine toxicology screen for Benzodiazepines?
SERTRALINE
Buspirone is thought to exert anxiolytic effects primarily due to its actions at which receptor?
5HT-1A
Benzo half-life < 6 hrs
TRIAZOLAM
Pharmacokinetic property most related to relative abuse potential of benzos
TIME TO ONSET OF ACTION
Benzodiazepam absorbed PO or IM
LORAZEPAM
Benzo w/o active metabolites
LORAZEPAM
Longest half-life amongst alprazolam, flurazepam, lorazepam, temazepam and triazolam
FLURAZEPAM (DALMANE) USED FOR INSOMNIA
Most common side effect of benzos
DROWSINESS
Which of the following benzos has an active metabolite?
CHLORDIAZEPOXIDE
Which of the following sleep changes is produced by all benzos?
DECREASE IN REM
Breakthrough panic anxiety in a patient treated with short-acting benzodiazepines can be managed by switching the pt to what medication?
CLONAZEPAM
75 y/o pt has developed tolerance to clonazepam over many years, now taking 5mg clonazepam at night but still with poor sleep. Pt denies any mood or anxiety symptoms, no drug problems. Next step:
SLOWLY WITHDRAW THE PT’S CLONAZEPAM AND REEVALUATE
Pts on chronic benzos develop:
AMNESIA
Benzo that would be the safest to prescribe for a 70y/o pt:
LORAZEPAM
35 yo patient presents with frequent panic attacks, which begin with feelings of dread, sweating, shaking, fear of doom and death lasting 20 min. Which medication provides immediate relief:
LORAZEPAM
How likely is escalation of benzodiazepine dose when prescribed for long term use?
MOST PATIENTS WILL MAINTAIN A STABLE DOSE OVER TIME
FDArequiresthatgenericsnotbesignificantlydifferentfromtheparentcompoundsinwhat way? (6x)
BIOEQUIVALENCE
After OD, pt has fever, confusion, tachycardia, dry mouth, urinary retention, dilated and unresponsive pupils. Which medication would treat this? (Anticholinergic toxicity) (4x)
PHYSOSTIGMINE
Pt presents to ED c/o ringing in ears, abdominal pain, and is found to have mild metabolic acidosis. Overdose of what substance? (4x)
ASPIRIN
Hepatitis C treatment with interferon can cause what psychiatric symptom? (3x)
DEPRESSION
Which of the following agents used to treat patients with Alzheimers disease has a mechanism of action related to an antiglutaminergic mechanism? (x2)
MEMANTINE
In addition to life support, which class of meds to consider for the treatment of neuroleptic malignant syndrome? (2x)
DOPAMINE AGONISTS (bromocriptine)
What medication may cause mood d/o in pts being treated for melanoma? Also worsens fatigue and cognitive inefficiency: (2x)
INTERFERON
What med is effective in tx of motor/vocal tics associated w Tourette syndrome refractory to tx with antipsychotics and alpha adrenergic agonists? (x2)
TETRABENAZINE
Pt confused, disoriented, dry mouth, dilated unresponsive pupils. Likely ingested: (2x)
BENZTROPINE
Flumazenil is used to treat: (2x)
BENZO INTOXICATION
This is a relative contraindication for interferon treatment in pt’s with Hepatitis C: (2x)
DEPRESSION WITH SUICIDAL IDEATION
The effects of caffeine on which of the following results in increased dopaminergic activity? (x2)
ADENOSINE RECEPTOR
A pt with cancer, pain, depressed mood, poor appetite, fatigue, impaired concentration, prognosis is less than three weeks. What should you treat with?
METHYLPHENIDATE
Contraindication for treatment for psychostimulants
UNDERLYING HEART DEFECT
54 yo female takes prozac 60 mg for MDD, having worsening migraines then fever, diarrhea, and “muscles are tightening up”. Which medicine is causing these sx?
SUMATRIPTAN
84 yo pt goes to ED with fever, dry mouth, visual hallucinations. Is found tachycardia, restless, toxicity of what medication most likely caused symptoms?
BENZTROPINE
Prolonged ingestion of high doses pyridoxine causes:
SUBACUTE SENSORY NEUROPATHY
Physostigmine is useful in treating toxic syndrome from overdose with:
SCOPOLAMINE
Pt in ED for treatment of OD – was found 4 hrs ago after ingesting 10 cold med packs of 650mg Tylenol, antihistamine, and alpha 1 agonist decongestant. Pt is pale and vomiting. How do you decide whether to use N-acetylcysteine as an antidote?
PT’S SERUM N-ACETYL-P-AMINOPHENOL (APAP) LEVEL OVER TIME
Tx of pts w/ substance abuse who have acute pain
PATIENT-CONTROLLED ANALGESIA
Which of the following agents has been shown to moderate weight gain in some pts treated w/ valproate and atypical antipsychotic?
METFORMIN
Pt took 20 tabs 500mg acetaminophen tabs 6 hours ago. Pt is 52kg, pulse 96, BP 135/65. Pt alert and in NAD. Serum acetaminophen level is 60 Ug/ml. Liver fxn test are minimally elevated. Most appropriate action?
N-ACETYL-CYSTEINE
A post-op pt’s was receiving 75mg IM meperidine. After switching to meperidine 100mg po pt reports inadequate pain relief. She has no past psych and abuse issues. This is due to:
THE LOWER POTENCY OF PO MEPERIDINE COMPARED TO IM
Acetylcysteine is Tx of choice for OD of:
ACETAMINOPHEN
OD on sleeping pill. Hot skin, blurry vision, urinary retention, dry mucous membranes, tachycardia, decreased bowel sounds. What is the pill?
DIPHENHYDRAMINE
Risk of hepatotoxicity will peak in how many hours after acetaminophen overdose?
72 TO 96 HOURS
MC complication of corticosteroid therapy?
MOOD DISORDER
Molecular targets for improving cognition in schizophrenia have shown promise via which of the following mechanisms?
D1 RECEPTOR AGONISM
Which med is helpful in Tourette Syndrome who can’t tolerate clonidine?
GUANFACINE
Guanfacine’s primary effect is through what mechanism of action?
PRESYNAPTIC ALPHA2 ADRENERGIC RECEPTOR ACTIVATION
Key element in emergency treatment of pt w serotonin syndrome, beyond stopping offending agent is:
SUPPORTING VITAL FUNCTIONS
Restlessness, myoclonus, hyperreflexia, diaphoresis, shivering, tremor, and confusion are compatible with which diagnosis?
SEROTONIN SYNDROME
Research on the use of psychostimulants to treat pts w/ secondary depressive symptoms in medical setting suggest:
WHEN TREATED WITH THESE AGENTS, PT MAY ENGAGE IN REHABILITATION SOONER.
A psychiatry consult is placed regarding a patient with SI. History of Bipolar disorder and admitted for VRE bacteremia. BP of 171/95, temp of 100.9. Has tremors, hyperreflexia, myoclonic jerks, not oriented at all, has visual hallucinations. Meds include linezolid, lithium, sertraline, Risperdal. What is diagnosis?
SEROTONIN SYNDROME
What drug has been known to cause hypertensive crisis?
PHENELZINE
African Americans tend to have higher activity of which of the following cytochrome p450 enzymes?
3A4
Sudden death in children taking which medication?
TRICYCLICS
47 yo pt presents with fever, confusion, and tremor and found to be tachy and diaphoretic. Clonus easily elicited on exam. Pt suspected to have serotonin syndrome, is taking Celexa and Lithium. What additional medication may have contributed to syndrome?
ST. JOHN’S WORT
Autonomic instability, nonfocal neurological signs, and elevated temp associated with which elevated lab value?
CREATININE PHOSPHOKINASE (CPK)
Drug-drug interactions in pts taking HIV meds are particularly problematic with which medication:
METHADONE
In addition to benzos, which class of meds is assoc with falls in pts older than 60?
ANTIDEPRESSANTS
The potency of medication refers to which of the following properties of a medication?
RELATIVE DOSE REQUIRED TO ACHIEVE A CERTAIN EFFECT
60 yo pt with chronic schizophrenia takes cogentin for neuroleptic induced parkinson now has increased urine retention and confusion. What medication would be the best alternative for treating this patient’s condition?
AMANTADINE
Most of the body’s serotonin is located where?
GI TRACT
Common side effect of acetylcholinesterase inhibitors
DIARRHEA
Diphenhydramine’s ability to treat acute dystonia is due to action on which receptor?
MUSCARINIC-1
28 y/o with BMDII wants to use phototherapy for depressive Sx treatment in winter. What should you advise?
CAN BE USED BUT REQUIRES VIGILANCE AND CAREFUL TITRATION OF DOSE
Which med is used to treat hep C viral infection and is associated with depression, anxiety, and cognitive impairment?
INTERFERON-ALPHA
In pts who surreptitiously use excess sulfonylurea, which of the following substances can be administered to r/o possible insulinoma?
TOLBUTAMIDE
Which of the following medications inhibits the enzyme ETOH acetaldehyde dehydrogenase?
DISULFIRAM
Buprenorphine’s advantages over clonidine, in the management of patients with opioid withdrawal, include better control of which of the following symptoms?
CRAVINGS
Therapeutic index is a relative measure of which of the following characteristics of a medication?
RELATIVE MEASURE OF DOSING TOXICITY TO SAFETY
Pharmacokinetic factor that declines w/ aging?
GLOMERULAR FILTRATION RATE
Patients >65 y/o are more sensitive to psych meds. What physiologic change occurs with aging?
DECREASED PHASE 1 OXIDATION
Agitated pt gets rapid tranquilization in ED. Using oral concentrate instead of IM or IV has what advantage?
DECREASED FEELINGS OF HELPLESSNESS
What herbal (phytomedicinal) is used as a hypnotic?
VALERIAN
The FDA requires that pharmaceutical companies demonstrate that a generic drug is not significantly different from the parent compound in which way?
BIOEQUIVALENCE
What is the underlying mechanism of action of sildenafil in erectile dysfunction?
ENHANCEMENT OF NITRIC OXIDE
What substance is associated with a risk of bleeding when taken with anti-platelet drugs or warfarin?
GINGKO BILOBA
Clonidine mechanism of action:
ALPHA-2 AGONIST
42 y/o pt has primary insomnia. Pt complains of difficulty falling asleep, but then sleeps through the night. Which of the following would be the best medication to prescribe for this pt after addressing sleep issues:
ZALEPLON