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A-CNS Pharma > Treatment of Neurodegenrative diseases > Flashcards

Treatment of Neurodegenrative diseases Flashcards

1
Q

بسم الله الرحمن الرحيم
__________________
Dementia means ?

A

Cognitive impairment including memory IN fully cosciouness person

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2
Q

Casues of dementia

A

Primary Alzhemir
Seondary:
Vacular = storke + infarction
Toxins
Tumor
infections
parkinson

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3
Q

pathopysiology of alzhemir

A

Extracullular accumulation of B-amyloid plaques
Intracellular accumulation of Tau protein
causing neuronal degenration especially the cholinergics

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4
Q

2 current therapies of Al-zhemir

A

Cholinimimetics
NMDA Receptor antagonist

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5
Q

Cholinestrase inhibitors ex

A

Donepazil oral
Rivastigmine oral and Transdermal patch

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6
Q

The only medication approved for Parkinson dementia ?

A

Rivastigmine

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7
Q

Mention adverse effects of Cholinesterase inhibitors

A

GIT : NVDA
Bradycardia
Muscle cramps
tremors
Drugn interactions involving CYP450 Except rivastigmine

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8
Q

Adventages of Rivastigmine ?

A

No drug interaction
Transdemal patch
used in Alzhemir dmentia the only drug !

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9
Q

Mematnie mechnaims describe

A

its is NMDA Receptor antagnist Preventing ca entering in huge amount preventing Apoptosis of neurons

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10
Q

Adverses of Memantine

A

Confusion Dizness headache constipation
Constipation

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11
Q

Depression and psychosis of alzemir treat ?>

A

Depression SSRI AND TCA
PSYCHOSIS AOR
Ariprazole
Olanzopine
Respridone

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12
Q

Autoimmnue inflammatory demyelinating disease of CNS

A

Multipe sclerosis
Chronic relapsing progressive disease

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13
Q

Mangemetn oF MS

A

Treatment of Acute episode
Disease modifying drugs
symptomatic treatment

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14
Q

Methylprednisolone dose and form in MS

A

For acute exacerbations release
1g/d IV for 5 days followd by tepered oral predinsone

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15
Q

Corticosteroids catabolic side effects

A

Catabolic :
Carbohydrate : hyperglycemia
Fat:lipolysis and fat distribuation
Protein = muscle wasting + Retardation of growth + osteoprosis
may cause pshcosis and depression

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16
Q

Corticosteriods cause edema and HTN why?

A

Due to salt and water retention

17
Q

Mention 3 side effects of Coricosteorids

A

Peptic ulcer
increase infections
Decreased wound healing + Hirsutism

18
Q

Disease modyfing drugs in MS

A

-INTF NATALI CHEMO
-1-Interferon B SC IM
-2-Figolimod Oral
-3-Natalizumab IV infusion
-4-Chemotheraputic agents as
cyclophospamide and azathioprine

19
Q

Fisrt line in modifying MS and its adverse effects

A

Interferon beta
Flu like symptoms
Depression
Reaction at site of injetion
AST and ALT ELEVATION

20
Q

First ORAL DMDS is ?

A

Fingilomod

21
Q

Lymphocyte sequestation done by?

A

Fingilimod
S1P1 attachement

22
Q

First dose bradycardia in DMDs by?>

A

Finglimoid

23
Q

Macular edema increased in DM in DMDs by?

A

Fingiliomd

24
Q

Finglimod adverses ?

A

Fist dose bradycardia
Increased Risk of infection
macualr edema

25
Q

Monoclonal antibody attaching to alpa 1 beta 4 integrin for no attahcment OF t cells to VCAM1 for no passing thorigh BBB TO CENTRAL NEURONS

A

NATALI
NATALIZIUMAB

26
Q

K channel blocker improving walking FDA has given it approval as a symptomatic treatment in MS ?

A

Dal Fampridine

27
Q

Fatigue = ?
muscle spasticiy= ?
Tremors
Neuralgia

A

modafinil
diazepam
inderal
carabamazpine antitiptyline

28
Q

Amyotrophic lateal scelrosis ALS

A

by genetic and ENVIRONMENTAL : Metals
pesticides
EMF

29
Q

dEGENRATION Of lateral coritcospinal upper motor also lower motor ccures in ?

A

ALS

30
Q

Theroetical pathophysiology of ALS ?

A

iNCREASED glutamate on NAMDA increasing intracellular calcium causing apoptisis

31
Q

Delaying need for ventilarot for 3months IN ALS ?

A

Rilozoule

32
Q

Delaying need for ventilarot for 3months IN ALS ?

A

Riluzole

33
Q

Rilzuole action ?

A

Blocking Na Channels preventing glutamate relase to NMDA ? Preventing Ca entery

34
Q

Rilzuole action ?

A

Blocking Na Channels preventing glutamate relase to NMDA ? Preventing Ca entery
so it is NMDA indirect antagonist right ?!

35
Q

الحمدلله رب العالمين

A

A-CNS Pharma (11 decks)

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