Migarane

Question 1

بسم الله الرحمن الرحيم
_______________
Triptans : -
Mechanism of action

Answer 1

Activates 5TH IB ID in presynaptic of trigeminal preventing VD neuropeptides release
Activating them on BVS causing VC

Question 1

بسم الله الرحمن الرحيم
_______________
Triptans : -
Mechanism of action

Answer 1

Activates 5TH IB ID in presynaptic of trigeminal preventing VD neuropeptides release
Activating them on BVS causing VC

Question 2

Preparation of triptan ?

Answer 2

sunatriptan
oral sc Nasal spray

Question 3

Mention triptans adverses

Answer 3

1-iNJECTIO SITE REACTION
Nasl= unpleasnt taste
2-Chest pressure
3-parathesia

Question 4

Contraindications of triptans

Answer 4

HPD
Uncontrolled HTN
Pregnancy
Diabetes
__________
Drug interaction with SSRI AND MAO

Question 5

Mechanisms of Ergots

Answer 5

5HT 1B 1D as triptans
+ Alpha 1 agonist

Question 6

Preparetions of ergots

Answer 6

Ergotamine tartate +caffine increasing absorption Sublingula oral and Rectal
DihydroErgotamine : IV IM SC intranasal

Question 7

Adverese effects of ergots?

Answer 7

Ergotism
Prolonged vasospams may cause gangrene angina whatever else + Fibrosis so CI In heart and pulmonary disease
CI in pregancny dure to uterine contraction
Chest pressure
GIT disturbances

Question 8

Prohylaxsis of migrane

Answer 8

hdc22
HTN:BB Timolol propranlol
Depression : Amitripyaline SSRI
Convulsions: Valproate and topriamate
CCBs: Verapamil