anitpsychotics Flashcards
بسم الله الرحمن الرحيم
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BLOCKING …….receptors in ……………. system improve positive symptoms of schziophrenia
D2 receptors in Mesolimbic system
blocking ….receptotrs in ,,,system imprves negative symptoms of schziphrenia
5HT2 receptors in mesocortical system
Thoiridiazine black box warning
Arryhtmia
incresing QT interval
Typical antipsychcotics should be used cautiosly in ?
Cardiac + Epiliptic patients
Cholestaic jaundice + Corneal deposits CC
occurs in ?
Typical antipshycotics
Blockage of D2 receptors
MCBH
1-Mesolimbic
2-CTZ anitemetic antihiccup
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1-Basal ganglia
-2Hypothalamus + pituirary
First line for akathesia ?
Propranolol
Dystonia + Parkinsonism of Extrapyramidal side effects of D2 blockade treated by ?
Anticholinergics
Benzotropine
EPS ?
ADPT
Akathesia
Dystonia
Parkinsonism
Tardive dyskinesia
Neuroleptic malignant hyperthermia
mention symptoms + tratment
symptoms MHT
Muscle rigidity + Hyperthermia Hypertension + Tachycardia
Treatment = 3DB
Discontinue antipsychotic + Diazepam and dantrolene as muscle releaxnt to improve hyperthermia + Bromocriptine increasing dopamine
1-contraidicated in Elderly + cardiac ?
2-Contraindicated in Parkinsonism perfered in cardiac ?
1-Chlorpromazine low potency
2-Halopridol high ptency
Fluoxetine and paroxetine CYP 450
Interacts with
antipscyhotics
IMI in agitation ?
Halopridol
Atypical antipsychotics has less extrapyramidal side effects + Hyperprolactenimeia except>?
Respridone !
antipsychotics of choice in parkinsonism ?
Clozapine + Quitapine
Resistant Schizphrnia
Reseistant psychosis ?
Colzapine
Agranulocytosis
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Clozapine also with ?
antiepiliptic carabmazebine
Side effects of clozapine
ISA
Insulin resistance
Seizure + nocturnal salivation
Agranulocytosis
Side effects of clozapine
ISA
Insulin resistance
Seizure + nocturnal salivation
Agranulocytosis
Galactorrhea
Gynecomastia
Increased QT interval ?
Repsirdone
Characteristic for Olanzopine ?
Increasing BOdy weight
Used in parkinsoisnm
Highly sedative
less EPS ?
qUITAPINE
Antipsychotic with EPS
Perfered in children for cognition
Perferred in Obeses
but problem is >? Akathesia
Arpiprazole
agitation
halpridol
antiemetic
anti hiccup ?
Chlorpromazine
Autism ?
Respridone + Arpiprazole
Lithium
mood stabilizer
Anti manic
anti derpessant
anti suicidal
Mention adverse effects and precuations of Lithium
CNS fINE tremors
GIT NVDA
if converted to Coarse tremors and increased Git symptoms =Warning signs of toxicity
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Renal :
Nephrotic diabetes inspidus Antagonizing ADH
Renal tubular damage so : Monitor kideny functiosn
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Hypothyoidism so monitos throyroid
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Why Lithium is toxic drug ?
narro theraputic index and Long T1/2
with cumulative effects
so Monitoring level and Adjusting doses is Obligatory !
Decreased excretion of Li due to?
Na depletion by diuretics
Renal dysfunction or due to old age
Lithium is …elminated
so good in …. impariment
so need dose adjustment in ?
Renally eleminated
Heaptic impairment
so need dose adjsutment in > renal dysfunction
Why Lithium is toxic drug ?
narro theraputic index and Long T1/2
with cumulative effects
so Monitoring level and Adjusting doses is Obligatory !
Decreased excretion of Li due to?
Na depletion by diuretics
Renal dysfunction or due to old age
Most effective in lithium toxicity ?
Hemodialysis
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