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A-CNS Pharma > anitpsychotics > Flashcards

anitpsychotics Flashcards

1
Q

بسم الله الرحمن الرحيم
______________
BLOCKING …….receptors in ……………. system improve positive symptoms of schziophrenia

A

D2 receptors in Mesolimbic system

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2
Q

blocking ….receptotrs in ,,,system imprves negative symptoms of schziphrenia

A

5HT2 receptors in mesocortical system

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3
Q

Thoiridiazine black box warning

A

Arryhtmia
incresing QT interval

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4
Q

Typical antipsychcotics should be used cautiosly in ?

A

Cardiac + Epiliptic patients

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5
Q

Cholestaic jaundice + Corneal deposits CC
occurs in ?

A

Typical antipshycotics

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6
Q

Blockage of D2 receptors

A

MCBH
1-Mesolimbic
2-CTZ anitemetic antihiccup
________________________
1-Basal ganglia
-2Hypothalamus + pituirary

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7
Q

First line for akathesia ?

A

Propranolol

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8
Q

Dystonia + Parkinsonism of Extrapyramidal side effects of D2 blockade treated by ?

A

Anticholinergics
Benzotropine

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9
Q

EPS ?

A

ADPT
Akathesia
Dystonia
Parkinsonism
Tardive dyskinesia

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10
Q

Neuroleptic malignant hyperthermia
mention symptoms + tratment

A

symptoms MHT
Muscle rigidity + Hyperthermia Hypertension + Tachycardia
Treatment = 3DB
Discontinue antipsychotic + Diazepam and dantrolene as muscle releaxnt to improve hyperthermia + Bromocriptine increasing dopamine

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11
Q

1-contraidicated in Elderly + cardiac ?
2-Contraindicated in Parkinsonism perfered in cardiac ?

A

1-Chlorpromazine low potency
2-Halopridol high ptency

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12
Q

Fluoxetine and paroxetine CYP 450
Interacts with

A

antipscyhotics

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13
Q

IMI in agitation ?

A

Halopridol

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14
Q

Atypical antipsychotics has less extrapyramidal side effects + Hyperprolactenimeia except>?

A

Respridone !

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15
Q

antipsychotics of choice in parkinsonism ?

A

Clozapine + Quitapine

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16
Q

Resistant Schizphrnia
Reseistant psychosis ?

A

Colzapine

17
Q

Agranulocytosis
مهم جدا جدا جدا جدا

A

Clozapine also with ?
antiepiliptic carabmazebine

18
Q

Side effects of clozapine

A

ISA
Insulin resistance
Seizure + nocturnal salivation
Agranulocytosis

19
Q

Side effects of clozapine

A

ISA
Insulin resistance
Seizure + nocturnal salivation
Agranulocytosis

20
Q

Galactorrhea
Gynecomastia
Increased QT interval ?

A

Repsirdone

21
Q

Characteristic for Olanzopine ?

A

Increasing BOdy weight

22
Q

Used in parkinsoisnm
Highly sedative
less EPS ?

A

qUITAPINE

23
Q

Antipsychotic with EPS
Perfered in children for cognition
Perferred in Obeses
but problem is >? Akathesia

A

Arpiprazole

24
Q

agitation

A

halpridol

25
Q

antiemetic
anti hiccup ?

A

Chlorpromazine

26
Q

Autism ?

A

Respridone + Arpiprazole

27
Q

Lithium

A

mood stabilizer
Anti manic
anti derpessant
anti suicidal

28
Q

Mention adverse effects and precuations of Lithium

A

CNS fINE tremors
GIT NVDA
if converted to Coarse tremors and increased Git symptoms =Warning signs of toxicity
____________________________
Renal :
Nephrotic diabetes inspidus Antagonizing ADH
Renal tubular damage so : Monitor kideny functiosn
________________
Hypothyoidism so monitos throyroid
_____________________________

29
Q

Why Lithium is toxic drug ?

A

narro theraputic index and Long T1/2
with cumulative effects
so Monitoring level and Adjusting doses is Obligatory !
Decreased excretion of Li due to?
Na depletion by diuretics
Renal dysfunction or due to old age

30
Q

Lithium is …elminated
so good in …. impariment
so need dose adjustment in ?

A

Renally eleminated
Heaptic impairment
so need dose adjsutment in > renal dysfunction

30
Q

Why Lithium is toxic drug ?

A

narro theraputic index and Long T1/2
with cumulative effects
so Monitoring level and Adjusting doses is Obligatory !
Decreased excretion of Li due to?
Na depletion by diuretics
Renal dysfunction or due to old age

31
Q

Most effective in lithium toxicity ?

A

Hemodialysis

32
Q

الحمدلله

A

A-CNS Pharma (11 decks)

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