Treatment of micturition and ED

Question 1

drugs for treatment disorders

Answer 1

Detrusitol XL
Neditol XL
Osybutynin XL

Question 2

treatment for ED

Answer 2

Phosphodiesterase-5 (PDE-5) inhibitors (Viagra®)
Prostaglandin E1 agonists, e.g. alprostadil (Caverject®, MUSE®)

Question 3

Tolterodine tartrate is an antimuscarinic used in the treatment of micturition, what is it marked as?

Answer 3

Detrol

Question 4

how many types of detrol

Answer 4

standard release and extended release (XL)

Question 5

Surelease: how is it made?

Answer 5

Ethylcellulose mixture is then emulsified with ammoniated water in a high shear mixer, i.e. homogeniser, aqueous dispersion

Question 7

How is the drug released?

Answer 7

by diffusion through ethylcellulose me,brane (ph change does not affect drug release)

Question 8

Tolterodine tartrate, why use small spheres?

Answer 8

stomach only empties its contents periodically – allows time for digestion to commence

small particles (2-3mm) pass through pyloric sphincter - separates stomach adn duodenum but large intact tablets cannot

small spheres can pass through pyloric sphincter irrespective of fed/fasting state

Question 9

Neditol® XL

Answer 9

generic) prolonged-released hard capsule dosage form for tolterodine tartrate

Question 10

Oxybutynin

Answer 10

antimuscarinic use in treatment of urge incontinene, increased urinary freq urgency and neurogenic bladder instability

Question 11

Dosage forms in which oxybutynin available:

Answer 11

Tablet
Modified-release tablet
Oral solution
Transdermal patch
Transdermal gel (not in the UK)

Question 12

ED treatment

Answer 12

Prostaglandin E1 agonists, e.g. alprostadil

Question 13

Caverject® (alprostadil) is administered by direct

Answer 13

intracavernous injection:

Question 14

Alprostadil is suspended in

Answer 14

macrogol 1450 and is formed into a urethral stick or suppository

a) Inserted into urethra 10-30 mins before intercourse