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CV PHARM...Intro to CV Pharmacology > Treatment of HTN > Flashcards

Treatment of HTN Flashcards

1
Q

ACEIs…drugs

A

“prils”

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2
Q

ACEIs…MOA

A

blocks formation of Ang II–>decrease in aldosterone

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3
Q

ACEIs…side effects/notes

A

(b/c increase in bradyokinin…) Cough!!!
hyperkalemia
angioedema
renal damage in pre-existing renal disease
***contraindicated in pregnancy

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4
Q

ARBs…drugs

A

“Sartans”

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5
Q

ARBs…MOA

A

Block Ang II at AT receptor–> decrease in aldosterone

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6
Q

ARBs…side effects

A

renal damage in pre-existing renal disease
hyperkalemia
**contraindicated in pregnancy

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7
Q

Renin inhibitor…drug

A

Aliskerin

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8
Q

Renin inhibitor…MOA

A

Decrease Ang I and therefore Ang II and aldosterone

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9
Q

Renin inhibitor…side effect

A

hyperkalemia

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10
Q

Thiazides…notes

A

useful in mild HTN

decrease K, Mg, Na

increase Ca, uric acid, glucose, LDL cholesterol, TGs

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11
Q

Loops…Notes

A

useful in moderate-severe HTN

decrease K, Mg, Ca, Na

increase uric acid, glucose, LDL cholesterol, TGs

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12
Q

Aldosterone antagonists…notes

A

Hyperkalemia
metabolic acidosis
gynecomastia
safe for use during pregnancy

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13
Q

Treatment of HTN during…
Pregnancy
GOOD!!!

A

alpha-methyldopa

hydralazine

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14
Q

Treatment of HTN during…
Pregancy
BAD!!!!

A

ACEIs and ARBs

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15
Q

Treatment of HTN during…
Diabetes
GOOD!!!!

A

ACEIs and ARBs

diuretics also good 2nd line agents

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16
Q

Treatment of HTN during…
Diabetes
BAD!!!!

A

b-blockers (high doses)

add-on use in low doses

17
Q

Treatment of HTN during…
Heart failure
GOOD!!!!

A

ACEIs

ARBs, diuretics (all classes)
select CCBs (amlodipine, felodipine)
18
Q

Treatment of HTN during…
Heart Failure
BAD!!!!!

A

B-blockers (high doses)
Verapamil
diltiazem

Add-on use w/ low dose BBs

19
Q

Treatment of HTN during…
COPD/asthma
GOOD!!!!

A

Calcium Channel Blockers

20
Q

Treatment of HTN during…
COPD/asthma
BAD!!!!!

A

non-selective b-blockers (high dose)

ACEIs (b/c chronic cough)

21
Q

Treatment of HTN during…
CKD
GOOD!!!!

A 
ACEIs and ARBs
Loop diuretics (don't use others w/ renal insufficiency)
22
Q

Treatment of HTN during…
BPH
Good!!!

A

alpha-blockers

23
Q

Treatment of HTN during…
Severe depression
BAD!!!!!

A

B-blockers
reserpine
alpha-methyldopa

24
Q

Treatment of HTN during…
Post MI
GOOD!!!

A

B-blockers
spironolactone
cardiac CCBs

ACEIs

25
Q

Treatment of HTN during…
prophylaxis of recurrent stroke
GOOD!!!!

A

Diuretics

ACEIs

CV PHARM...Intro to CV Pharmacology (7 decks)

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