Digoxin Flashcards
1
Q
Na/K ATPase inhibition–>
A
intracellular increase in Na and decrease in K–>
2
Q
activation of Na/Ca exchanger–>
A
increase in Ca–> decreased cellular polarization
3
Q
increase in intracellular Ca (effect on myocardium)
A
inotropic effect–>
increased CO–>decreased sympathetic tone—->Vasodilation
4
Q
increase in intracellular Ca (effect on VSM tone)
A
increased VSM tone
vasoconstriction
5
Q
Digoxin pks
A
very narrow therapeutic window
6
Q
Important digoxin side effects
A
visual disturbances!!! (halo)
7
Q
Digoxin antidote
A
Digibind
