Treatment of haematologic malignancies AB

Question 1

Treatment of asymptomatic CLL

Answer 1

Observation unless cytopaenias or evidence of progressive disease

Question 2

Treatment of symptomatic or progressive CLL

Answer 2

Gold standard: Fludarabine / CYC / Ritux

Old/frail: Chlorambucil + Pred

Question 3

Multiple myeloma fit for ASCT: induction, consolidation and maintenance?

Answer 3

Induction: Bortezomib + Dex +/- Thalidomide
Consolidation: Melphalan/ASCT
Maintenance: Thalidomide +/- Pred

Question 4

Treatment of relapsed CLL

Answer 4

Chemo +/- MAb

e.g. Ibrutinib (Bruten’s TK inhibitor)

Question 5

What is a significant adverse effect of arsenic given in APML?

Answer 5

Torsades

Question 6

Blinotimumab - given in which condition?

Answer 6

Refractory/relapsed ALL

Question 7

Blinotimumab - mAb against what?

Answer 7

CD19/CD3