Prognostic markers in haematologic malignancy AB

Question 1

CLL cytogenetics - good prognostic marker/s?

Answer 1

13q deletion

Question 2

CLL cytogenetics - poor prognostic marker/s?

Answer 2

11q deletion, 17q deletion

Question 3

CLL molecular testing - prognostic marker?

Answer 3

IgH unmutated = poor
IgH mutated = good

Born bad, behave bad.
Become bad, able to be rehabilitated.

Question 4

CLL immunophenotyping - poor prognostic markers?

Answer 4

ZAP-70 = bad
CD38 = bad

Question 5

What is the strongest predictor of prognosis in AML?

Answer 5

Age >60

Question 6

AML - good cytogenetics?

Answer 6

Even numbers and APML

t(15;17)
t(8;21)
Inv(16)

Question 7

AML - bad cytogenetics?

Answer 7

Odd numbers

inv(3)
del(5)
del(7)
t(3;3)
t(6;9)
t(9;22) - BCR:ABL
11q23
Complex cytogenetics

Question 8

What targets FLT3-ITD?

Answer 8

Sorafenib

Question 9

ALL - good cytogenetics?

Answer 9

Hyperdiploidy
t(12;21)
(1;19)

Question 10

ALL - bad cytogenetics?

Answer 10

t(9;21) - majority of adults

MLL

Question 11

What’s the alternative marker to JAK2 in myelofibrosiss?

Answer 11

Calreticulin