Anaemias and haemoglobinopathies AB

Question 1

What are the causes of acquired sideroblastic anaemia?

Answer 1

Lead poisoning
Alcohol
Anti-TB medications
Myelodysplasia

Question 2

What is the treatment of sideroblastic anaemia

Answer 2

Treat underlying cause

Pyridoxine may help

Question 3

Which drugs cause pancytopaenia?

Answer 3

Cytotoxics
Antibiotics: trimethoprim, chloramphenicol
Anti-rheumatoid: gold, penicillamine
Carbimazole
Carbamazepine

Question 4

What are 2 causes of spherocytosis on peripheral blood film?

Answer 4

Hereditary spherocytosis

Immune haemolytic anaemia

Question 5

In what conditions do you see microspherocytosis on peripheral blood film?

Answer 5

Clostridial sepsis
Burns
MAHA

Question 6

In what conditions do you see schistocytes on peripheral blood film?

Answer 6

TTP/HUS
DIC
Mechanical haemolysis

Question 7

In what condition do you see prickle cells on peripheral blood film?

Answer 7

Pyruvate kinase (Pk) deficiency

Question 8

In what condition do you see acanthocytes on peripheral blood film?

Answer 8

Advanced liver disease - spur cell haemolytic anaemia

Question 9

In what condition do you see agglutination on peripheral blood film?

Answer 9

Cold antibody immune haemolytic anaemia

Question 10

What are the findings suggestive of oxidative stress on peripheral blood film?

Answer 10

Bite cells
Irregularly contracted cells
Heinz bodies

Question 11

What is the most sensitive test and what is the most specific test for pernicious anaemia?

Answer 11

Sensitive: anti-parietal cell antibodies

Specific: anti-intrinsic factor antibodies