Treatment in psychiatry Flashcards
SSRI S/E
Serotonin syndrome S/E
Antidepressant
9 classes
- Selective serotonin reuptake inhibitor (SSRI)
- Serotonin noradrenergic reuptake inhibitor (SNRI), eg. venlafaxine, desvenlafaxine, duloxetine
- Noradrenaline and dopamine reuptake inhibitor (NDRI), eg. bupropion
- Selective noradrenergic reuptake inhibitor (NRI), eg. reboxetine
- Serotonin antagonist and reuptake inhibitor (SARI), eg. trazodone
- Noradrenaline antagonist and selective serotonergic antidepressant (NaSSA), eg. mirtazapine
- Melatonin receptor agonist, eg. Agomelatine
- Tricyclic antidepressants (TCAs) eg. amitriptylline, clomipramine
- Monoamine oxidase inhibitor (MAOI), eg. Moclobemide
Antipsychotics
Dopamine pathways
Dopaminergic side effects
EPSE types
Acute dystonia EPSE
Features
Treatment
Parkinsonism EPSE
Treatment
Akathisia EPSE
Feature
Treatment
Tardive dyskinesia
Feature
Treatment
Neuroleptic malignant syndrome
Features
Treatment
Non-dopaminergic side effects anti-psychotics
Mood stabilizer
Types
Lithium
Pre-treatment preparation
Monitoring timing
On treatment monitoring
Discontinuation method
Lithium C/I
DDI- Diuretics- NSAID- CCB- ACEi
Lithium S/E
Lithium toxicity
Level
Management
BZD types
BZD side effects
BZD
Tolerance and withdrawal and toxicity management
Pregabalin
S/E
Z drug
MoA
S/E
MOA
- Binds selective to BZ1 subtype GABA-receptors
- Facilitate GABA-mediated chloride influx and neuronal inhibition
- Antagonised by Flumazenil (competitive antagonist of binding site)
Special SE:
- Zolpidem: Sleepwalking
- Zopiclone: Methaemoglobinaemia
Buspirone
MoA
ADR
DDI
MAOI
MoA
ADR
Caution with which food and drugs
TCA
MoA
ADR
Tricyclic/ Tetracyclic Antidepressants (TCA) Psychiatry e.g. Amitriptyline, Clomipramine, Imipramine, Nortriptyline, Prothiaden
SSRI
Types
Which has least DDI
SSRI
ADR
DDI
NRI/ NDRI/ SNRI/ SARI examples
NASA example
MRA
example
Special SE
SSRI
Specific receptor types SE
Specific ADR of TCA, SARI, NASA, SNRI, MRA
Valproate
MoA
ADR
DDI
Lamotrigine
Use
ADR
DDI
Carbamazepine
ADR
Mood stabilisers in pregnancy
Compare FGA and SGA
Antipsychotic
Specific receptors and SE
EPSE
Types
Mx