Treatment for restrictive

Question 1

Drugs for idiopathic Pulmonary Fibrosis

Answer 1

For mild and moderate idiopathic pulmonary fibrosis

Pirfenidone = Reduces disease progression and preserves lung function.

Nintedanib= slows the disease progression.

Question 2

Pirfenidone

Answer 2

Drug for Idiopathic pulmonary fibrosis. Slows the progression.

Inhibits transforming growth factor beta (TGF beta) ( this is for scar formation)

Blocks fibroblast proliferation and collagen synthesis
decreases the extracellular matrix

Side effect:
1. Photosensitivity and rash
2. Elevated liver enzymes

Question 3

Nintedanib

Answer 3

Drug for Idiopathic pulmonary fibrosis. Reduced the progression

Inhibits multiple receptor tyrosine kinases for example:
1. Platelet derived growth factor receptor
2. Fibroblast growth factor receptor
3. Vascular endothelial growth factor receptor

Blocks fibroblast activation and proliferation

Side effect:
1. Diarrhea, nausea and vomiting
2. Elevated Liver enzymes
3. increase risk of arterial thromboembolic events
4. Bleeding risk due to inhibition of VEGF
5. Fatigue and weight loss

Question 4

Drug induce Pulmonary fibrosis

Answer 4

1. Bleomycin
2. Busulfan
3. Methotrexate
4. Amiodarone +++++
5. Nitrofurantoin
6. Leflunomide
7. Infliximab, etanercept, adalinumab
8. gefitinib and erlotinib